Luis S Gonzalez

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BACKGROUND Various strategies have been introduced to minimize transfusion requirements in cardiac surgery. One strategy is the use of positive end-expiratory pressure (PEEP) postoperatively. Currently, PEEP is used in many centers to control increased mediastinal chest-tube drainage. The purpose of this study was to determine whether the prophylactic(More)
Aminoglycosides are potent bactericidal antibiotics that act by creating fissures in the outer membrane of the bacterial cell. They are particularly active against aerobic, gram-negative bacteria and act synergistically against certain gram-positive organisms. Gentamicin is the most commonly used aminoglycoside, but amikacin may be particularly effective(More)
Prescribing medications for a breast-feeding mother requires weighing the benefits of medication use for the mother against the risk of not breast-feeding the infant or the potential risk of exposing the infant to medications. A drug that is safe for use during pregnancy may not be safe for the nursing infant. The transfer of medications into breast milk(More)
OBJECTIVE Spontaneous subarachnoid hemorrhage (SAH) causes a prolonged corrected QT interval (QTc) in 25% to 90% of patients, but whether this occurs with traumatic SAH (tSAH) is unknown. This investigation was conducted to determine whether QTc prolongation occurs with tSAH and to evaluate QTc prolongation with respect to severity of tSAH. DESIGN Records(More)
Coagulopathy is the inability of blood to coagulate normally; in trauma patients, it is a multifactorial and complex process. Seriously injured trauma patients experience coagulopathies during the acute injury phase. Risk factors for trauma-induced coagulopathy include hypothermia, metabolic acidosis, hypoperfusion, hemodilution, and fluid replacement. In(More)
Antibiotic resistance of Streptococcus pneumoniae is on the rise in many parts of the world, and varies widely across the United States. This is of growing concern as organisms become resistant to cephalosporins and macrolides as well as to beta-lactam antibiotics. Susceptibility testing has become a critical element in antibiotic selection. In vitro(More)