Luis Pinheiro

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The human blood-brain barrier (BBB) is a membrane that protects the central nervous system (CNS) by restricting the passage of solutes. The development of any new drug must take into account its existence whether for designing new molecules that target components of the CNS or, on the other hand, to find new substances that should not penetrate the barrier.(More)
Congenital Cytomegalovirus (CMV) infection occurs in about 1% of the newborns, but it is clinically unapparent in around 90% of the cases during the newborn period. This congenital infection may be the cause of neurological sequelae of variable severity, namely neuro-sensorial hearing loss. In most cases of hearing loss secondary to congenital CMV(More)
The radiologic criteria are important for the diagnosis of silicosis and must be objective. Initial radiologic changes are nonspecific and sometimes misinterpreted. We asked six Pulmonologists with distinct training in pulmonary disease to interpret 112 chest films according to a simple established protocol. No further information was given. One year later,(More)
INTRODUCTION AND OBJECTIVES Atrial fibrillation is the most prevalent sustained arrhythmia. This paper estimates the burden and cost of illness attributable to atrial fibrillation in Portugal based on demographic and health statistics. METHODS Mortality data by cause of death came from the European Detailed Mortality Database of the World Health(More)
INTRODUCTION In Portugal, the epidemiology of acute pulmonary embolism is poorly understood. In this study, we sought to characterize the pulmonary embolism from the hospital data and evaluate its in-hospital mortality and respective prognostic factors. MATERIAL AND METHODS The study used diagnostic related groups data from National Health System(More)
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