Luis Miguel Ruilope-Urioste

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BACKGROUND Even within the normal range, aldosterone levels are linked to end-organ toxicity and mortality in patients with hypertension. Treatment with angiotensin-converting enzyme inhibitors or angiotensin-receptor blockers does not sufficiently reduce plasma aldosterone levels. OBJECTIVE This study was conducted to assess the long-term safety profile(More)
OBJECTIVE To define the influence of dietary salt intake on the antihypertensive effect of slow-release verapamil 240 mg once a day in a population with mild-to-moderate essential hypertension. DESIGN Parallel, randomized, multicentre study. METHODS Patients were advised to follow a moderately low salt diet (Low-salt group). After a 2-week run-in(More)
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