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OBJECTIVES To develop a consensus document of recommendations for the use of methotrexate (MTX) in patients with juvenile idiopathic arthritis (JIA). MATERIAL AND METHOD A group of eleven experts proposed several clinical questions on the use of MTX in patients with JIA. A systematic review was conducted and the evidence and recommendations for each(More)
Alpha-solamargine isolated from the fresh fruits of Solanum americanum Miller was studied for its toxicity. Lethality studies in rats showed a dose-mortality relationship with a LD(50) of 42 mg/kg body weight intraperitoneally. The chronic and subchronic toxicity investigations indicated that the size of the glycoalkaloid dose was more important than the(More)
A therapeutic essay was done to determine the effects of N-Acetylcysteine (NAC), Methionine (MET) and the NAC + MET combination on the lead (Pb) blood levels, the malondialdehide (MDA) and catalase activity (CAT) in cerebellum of rats treated with 0.5 and 2 microg/g of Pb acetate. One hundred ninety eight male Wistar rats with an average weight of 240 g(More)
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