Luis Garcia Dominguez

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The scientific study of subjective experience is a current major research area in the neurosciences. Coordination patterns of brain activity are being studied to address the question of how brain function relates to behaviour, and particularly methods to estimate neuronal synchronization can unravel the spatio-temporal dynamics of the transient formation of(More)
Synchronization is a fundamental characteristic of complex systems and a basic mechanism of self-organization. A traditional, accepted perspective on epileptiform activity holds that hypersynchrony covering large brain regions is a hallmark of generalized seizures. However, a few recent reports have described substantial fluctuations in synchrony before and(More)
Traumatic brain injury (TBI) is the leading cause of death and acquired disability in the pediatric population worldwide. We hypothesized that electroencephalography (EEG) synchrony and its temporal variability, analyzed during the acute phase following TBI, would be altered from that of normal children and as such would offer insights into TBI(More)
The analysis of synchronization, particularly phase locking , is being increasingly used in neuroscience to explore coordinated brain activity. The application of this methodology to magnetoencephalographic (MEG) and electro-encephalographic (EEG) recordings would seem promising because these two recording techniques have great temporal resolution. However,(More)
Abnormal gamma-aminobutyric acid inhibitory neurotransmission is a key pathophysiological mechanism underlying schizophrenia. Transcranial magnetic stimulation can be combined with electroencephalography to index long-interval cortical inhibition, a measure of GABAergic receptor-mediated inhibitory neurotransmission from the frontal and motor cortex. In(More)
The identification of epileptic seizure precursors has potential clinical relevance. It is conjectured that seizures may be represented by dynamical bifurcations and that an adequate order parameter to characterize brain dynamics is the phase difference in the oscillatory activity of neural systems. In this study, the critical point hypothesis that(More)
Coordinated cellular activity is a major characteristic of nervous system function. Coupled oscillator theory offers unique avenues to address cellular coordination phenomena. In this study, we focus on the characterization of the dynamics of epileptiform activity, based on some seizures that manifest themselves with very periodic rhythmic activity, termed(More)
The glutamic acid decarboxylase 1 (GAD1) gene is a major determinant of γ-aminobutyric acid (GABA), the most abundant inhibitory neurotransmitter modulating local neuronal circuitry. GABAergic dysfunction and expression of GAD1 have been implicated in the pathophysiology of schizophrenia, and in working memory impairment. We examined the influence of the(More)
This comment constitutes a re-assessment of a recent study in which near-infrared spectroscopy (NIRS) was used to decode decision making. In the original study, the process of feature selection was carried out on all of the data, and those features which displayed the greater classification accuracy were selected, but no independent assessment or validation(More)
OBJECTIVE Long-interval cortical inhibition (LICI) can be recorded from motor and non-motor regions of the cortex through combined transcranial magnetic stimulation (TMS) with electroencephalography (EEG). This study aimed to evaluate additional dimensions of LICI characteristics over an extended time-frequency and spatial domain. This was done by(More)