Luis Agüera

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OBJECTIVE To review the pharmacological basis of antidepressant potentiation in combination therapy and the clinical evidence for its efficacy. METHOD Literature searches were undertaken and the results reviewed. RESULTS Treatment-resistant depression is common (15-30%). Various strategies exist for dealing with resistant depression, including(More)
BACKGROUND Patients with chronic pain frequently display comorbid depression, but the impact of this concurrence is often underestimated and mistreated. The aim of this study was to determine the prevalence of unrecognized major depression and other mood disorders and comorbid unexplained chronic pain in primary care settings and to explore the associated(More)
OBJECTIVE To review the current literature on the use of combinations of antidepressive agents. METHOD Literature searches were undertaken and reviewed on the use of combinations of antidepressants. RESULTS Data sources included surveys, analyses of prescription records, decision algorithms, clinical reports, and studies comparing the monotherapy with(More)
OBJECTIVE The present study uses the data from a large survey conducted to examine the general practice of Spanish psychiatrists on the use of antidepressant combinations in the treatment of depressive disorders. METHOD The sample was drawn from specialists and psychiatric residents practicing in Spain who were respondents to a questionnaire distributed(More)
OBJECTIVE To review the neuropharmacological basis of antidepressant combination therapy. METHOD Literature searches and other relevant material were obtained and reviewed. RESULTS The overall clinical aim of combining antidepressants is to increase the efficacy whilst minimizing the side effects. Although such prescriptions are frequently based on the(More)
OBJECTIVE To evaluate the treatment options in patients who do not respond appropriately to a single antidepressant alone. METHOD The medical literature was reviewed. RESULTS A number of strategies are available if a patient fails to respond adequately to initial antidepressant treatment, including the combination with another psychoactive drug.(More)
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