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The therapeutic promise of induced pluripotent stem cells (iPSCs) has spurred efforts to circumvent genome alteration when reprogramming somatic cells to pluripotency. Approaches based on episomal DNA, Sendai virus, and messenger RNA (mRNA) can generate "footprint-free" iPSCs with efficiencies equaling or surpassing those attained with integrating viral(More)
and the values they have taught, and for instilling in me a drive to " do my best " in whatever I choose to do. iv Acknowledgements This work would not have been possible without the help and support of many individuals. the opportunity to work in an exciting multidisciplinary lab on a variety of interesting projects. The past several years have enabled me(More)
Overview of group: Our lab is developing high-throughput high-content technologies for investigating the complex development, function, reprogramming, degeneration and regeneration of the nervous system. We employ a variety of techniques including micromanipulation, microfluidics, ultrafast optics, advanced microscopy, quantum physics, genetics, and(More)
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