Luigi Gatta

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OBJECTIVE To do a systematic review and meta-analysis of studies comparing sequential therapy for eradication of Helicobacter pylori with pre-existing and new therapies, thus providing a glimpse of eradication success worldwide. DESIGN Systematic review and meta-analysis. DATA SOURCES Medline, Embase, and Cochrane Central Register of Controlled Trials(More)
Helicobacter pylori infection remains widespread internationally, with a definite morbidity and mortality. The efficacy of standard 7-14 day triple therapies is decreasing, mainly due to increasing primary bacterial resistance to antibiotics. Currently, the most effective treatments are either the sequential regimen or the concomitant therapy. Different(More)
BACKGROUND The prevalence of resistance to clarithromycin and metronidazole has considerably increased, with a corresponding decrease in the eradication rate for Helicobacter pylori (H. pylori) infection. Primary resistance to amoxicillin is extremely low, and esomeprazole was found to exert a noteworthy antimicrobial activity in vitro against H. pylori. A(More)
BACKGROUND The introduction of proton pump inhibitors (PPIs) into clinical practice has revolutionized the management of acid-related diseases. Studies in primary care and emergency settings suggest that PPIs are frequently prescribed for inappropriate indications or for indications where their use offers little benefit. Inappropriate PPI use is a matter of(More)
In the last decades, the incidence of gastric cancer has decreased in Western countries, whilst that of gastroesophageal junction has progressively increased [1]. Th is has triggered a lot of studies aiming to unveil environmental causes potentially involved in these trends [2]. Th e reduction in Helicobacter pylori (H. pylori) infection rate in the general(More)
Background Helicobacter pylori (H. pylori) treatment remains a challenge for physicians. Although highly eff ective, the standard sequential therapy fails in a certain number of patients. Moreover, the cure rate following a levofl oxacin-amoxicillin second-line triple therapy seems to be decreasing. We tested the effi cacy of modifi ed 10-day sequential(More)
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