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Dear Sirs, Subarachnoid haemorrhage (SAH) is a serious condition that has a young age onset and poor outcome [1]. Approximately 75% of the cases of SAH is due to the rupture of an intracranial aneurysm (IA) [1]. The most important risk factors are smoking, hypertension, and excessive alcohol intake [1]. In addition, genetic factors have been shown to play(More)
OBJECT Family studies have suggested a role of genetic factors in susceptibility to aneurysmal subarachnoid hemorrhage (aSAH), but the underlying genetic risk factors remain poorly defined. There is an activation of the fibrinolytic system in aSAH, and fibrinolytic markers may be useful in predicting outcome. The authors investigate associations between(More)
Severe traumatic brain injury (TBI) may result in widespread damage to axons, termed diffuse axonal injury. Alzheimer’s disease (AD) is characterised by synaptic and axonal degeneration together with senile plaques (SP). SP are mainly composed of aggregated β-amyloid (Aβ), which are peptides derived from the amyloid precursor protein (APP). Apart from TBI(More)
BACKGROUND AND AIM Genetic factors play a role in susceptibility to subarachnoid haemorrhage, but little is known about which genes are involved. Recently, genome wide association studies have identified the 9p21 region as a risk locus for intracranial aneurysms (IA). The aim of the present study was to examine the possible association between 9p21 and(More)
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