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BACKGROUND Phase I clinical studies have demonstrated the feasibility of implanting autologous skeletal myoblasts in postinfarction scars. However, they have failed to determine whether this procedure was functionally effective and arrhythmogenic. METHODS AND RESULTS This multicenter, randomized, placebo-controlled, double-blind study included patients(More)
BACKGROUND Carotid stenting is a potential alternative to carotid endarterectomy but whether this technique is as safe as surgery and whether the long-term protection against stroke is similar to that of surgery are unclear. We previously reported that in patients in the Endarterectomy Versus Angioplasty in Patients with Symptomatic Severe Carotid Stenosis(More)
BACKGROUND We aimed to determine the representation of elderly people in published reports of randomized controlled trials (RCTs). We focused on trials of 4 medications--pioglitazone, rosuvastatin, risedronate, and valsartan-frequently used by elderly patients with chronic medical conditions. METHODS AND FINDINGS We selected all reports of RCTs indexed in(More)
OBJECTIVE To compare estimates of intervention effects between single centre and multicentre randomised controlled trials with continuous outcomes. DESIGN Meta-epidemiological study. DATA SOURCES 26 meta-analyses totalling 292 randomised controlled trials (177 single centre, 115 multicentre) with continuous outcomes published between January 2007 and(More)
OBJECTIVE To assess the influence of trial sample size on treatment effect estimates within meta-analyses. DESIGN Meta-epidemiological study. DATA SOURCES 93 meta-analyses (735 randomised controlled trials) assessing therapeutic interventions with binary outcomes, published in the 10 leading journals of each medical subject category of the Journal(More)
Scientific peer-review and publication systems incur a huge burden in terms of costs and time. Innovative alternatives have been proposed to improve the systems, but assessing their impact in experimental studies is not feasible at a systemic level. We developed an agent-based model by adopting a unified view of peer review and publication systems and(More)
OBJECTIVE To examine whether network meta-analyses, increasingly used to assess comparative effectiveness of healthcare interventions, follow the key methodological recommendations for reporting and conduct of systematic reviews. DESIGN Methodological systematic review of reports of network meta-analyses. DATA SOURCES Cochrane Database of Systematic(More)
BACKGROUND Indirect comparisons of competing treatments by network meta-analysis (NMA) are increasingly in use. Reporting bias has received little attention in this context. We aimed to assess the impact of such bias in NMAs. METHODS We used data from 74 FDA-registered placebo-controlled trials of 12 antidepressants and their 51 matching publications. For(More)
BACKGROUND Representative national data on disability are becoming increasingly important in helping policymakers decide on public health strategies. We assessed the respective contribution of chronic health conditions to disability for three age groups (18-40, 40-65, and >65 years old) using data from the 2008-2009 Disability-Health Survey in France. (More)
BACKGROUND The earliest changes associated with airflow obstruction in asthmatic children are a proportionally greater reduction in FEF(50%) than in FEV(1) using spirometry, and an increase in specific airway resistance (sRaw) using body plethysmography. Consequently, we hypothesized that sRaw could be better linked to FEF(50%) than to FEV(1). The first aim(More)