Ludovic Trinquart

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OBJECTIVE To compare estimates of intervention effects between single centre and multicentre randomised controlled trials with continuous outcomes. DESIGN Meta-epidemiological study. DATA SOURCES 26 meta-analyses totalling 292 randomised controlled trials (177 single centre, 115 multicentre) with continuous outcomes published between January 2007 and(More)
BACKGROUND We aimed to determine the representation of elderly people in published reports of randomized controlled trials (RCTs). We focused on trials of 4 medications--pioglitazone, rosuvastatin, risedronate, and valsartan-frequently used by elderly patients with chronic medical conditions. METHODS AND FINDINGS We selected all reports of RCTs indexed in(More)
OBJECTIVE To examine whether network meta-analyses, increasingly used to assess comparative effectiveness of healthcare interventions, follow the key methodological recommendations for reporting and conduct of systematic reviews. DESIGN Methodological systematic review of reports of network meta-analyses. DATA SOURCES Cochrane Database of Systematic(More)
BACKGROUND Indirect comparisons of competing treatments by network meta-analysis (NMA) are increasingly in use. Reporting bias has received little attention in this context. We aimed to assess the impact of such bias in NMAs. METHODS We used data from 74 FDA-registered placebo-controlled trials of 12 antidepressants and their 51 matching publications. For(More)
Scientific peer-review and publication systems incur a huge burden in terms of costs and time. Innovative alternatives have been proposed to improve the systems, but assessing their impact in experimental studies is not feasible at a systemic level. We developed an agent-based model by adopting a unified view of peer review and publication systems and(More)
BACKGROUND Representative national data on disability are becoming increasingly important in helping policymakers decide on public health strategies. We assessed the respective contribution of chronic health conditions to disability for three age groups (18-40, 40-65, and >65 years old) using data from the 2008-2009 Disability-Health Survey in France. (More)
OBJECTIVE To assess the influence of trial sample size on treatment effect estimates within meta-analyses. DESIGN Meta-epidemiological study. DATA SOURCES 93 meta-analyses (735 randomised controlled trials) assessing therapeutic interventions with binary outcomes, published in the 10 leading journals of each medical subject category of the Journal(More)
We present a novel method for adaptation of existing terminologies. Within biomedical domain and when no textual corpora for building terminologies are available, we exploit UMLS metathesaurus which merges over a hundred existing biomedical terminologies and on-tologies. We exploit also algorithms for measuring the semantic similarity in order to limit,(More)
  • Ryan T. Demmer, Ludovic Trinquart, Aleksandra Zuk, Benjamin C. Fu, Josefin Blomkvist, Bryan S. Michalowicz +2 others
  • 2013
BACKGROUND Periodontal infections are hypothesized to increase the risk of adverse systemic outcomes through inflammatory mechanisms. The magnitude of effect, if any, of anti-infective periodontal treatment on systemic inflammation is unknown, as are the patient populations most likely to benefit. We conducted a systematic review and meta-analysis of(More)
BACKGROUND Network meta-analysis (NMA), a generalization of conventional MA, allows for assessing the relative effectiveness of multiple interventions. Reporting bias is a major threat to the validity of MA and NMA. Numerous methods are available to assess the robustness of MA results to reporting bias. We aimed to extend such methods to NMA. METHODS We(More)