Ludmila Sazonova

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Nitroglycerin, isosorbide dinitrate and sodium nitroprusside, like nifedipine, were found to inhibit the receptor-provoked increase of cytosolic free calcium concentration in human platelets loaded with 2-[(2-amino-5-methylphenoxy)methyl]-6-methoxy-8-aminoquinoline-N,N,N',N' - tetraacetate. Sodium nitroprusside and nitroglycerin induced elevation of cyclic(More)
15 patients with primary pulmonary hypertension (PPH) were studied. An acute test with 20 mg nifedipine (N) sublingually was performed and the pulmonary artery pressure (PAP) was measured. N had manifest arterolodilating effect in the systemic and especially pulmonary circulation, induced decrease in the total peripheral and total pulmonary vascular(More)
The efficacy of peripheral vasodilators with various mechanisms of action was studied in 26 patents with congestive heart failure, left ventricular dilatation and valvular regurgitation. An acute pharmacological test using prazosin was used in all the patients, 20 of them were given a 15-day course of prazosin therapy, 19 patients received a prolonged(More)
Regional hemodynamics using plethysmography and tissue oxygen tension at the basal level and during corinfar administration were investigated in 38 patients with heart failure against a background of rheumatic heart valvular diseases, dilatation cardiomyopathy and coronary heart disease. A considerable decrease in regional vascular resistance (RVR) and(More)