Ludmila I Gapon

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A study was made of transmembranous ionic transport enzymes (Na(+)-K(+)-, Mg2(+)- and Ca2(+)-ATPases) in 95 patients with essential hypertension (EH) and 39 healthy persons. The activity of Na(+)-K(+)-ATPase was decreased for the most part at the early stages of EH. Measurements of the content of natriuretic hormone in the plasma did not reveal any(More)
Increased blood pressure and reduced robustness of circadian rhythms are frequently reported in elderly subjects. The present study was aimed to investigate whether such changes can be reversed by daily melatonin ingestion. 97 normotensive and hypertensive volunteers of both genders and 63 to 91 years old participated. They lived in the Tyumen Elderly(More)
AIM To elucidate effect of nebivolol on parameters of cerebral hemodynamics and 24-hour blood pressure (BP) profile in patients with hypertension. MATERIAL AND METHODS Patients with hypertension of 2nd degree (n=55, age 35-50 years) were divided into 2 groups with similar age, sex, duration of hypertension, and office BP level. Thirty one patients(More)
The objective of this study was to evaluate effect of "dry" bi-carbonate baths (DBB) on the circadian profile of arterial pressure (AP) in patients who suffered acute myocardial infarction (AMI). Diurnal AP profiles were analysed in all patients after AMI. The patients comprising group 1 were treated with the use of DBB while the remaining ones received a(More)
A placebo-controlled parallel trial studied an antihypertensive action of interrupted normobaric hypoxia (INH) in 63 male patients with arterial hypertension (AH) of the first degree and low and moderate risk of vascular complications. The placebo group consisted of 18 patients with AH of the first degree matched by age, the disease duration, initial level(More)
Beta-blocker anapriline and calcium antagonist corinfar are highly effective hypotensive agents. Drop in diastolic arterial pressure with anapriline therapy amounted to 15.9 and 15.6%, with corinfar therapy-to 15.0 and 15.6% in hypertensive disease stage I and II respectively. Hypotensive action of corinfar might result from correction of impaired(More)
A study is presented of the activity of Na(+)- K(+)-, Mg2(+)- and Ca2(+)-ATP-ases, lipid spectrum of the erythrocytic membranes and the content of intracellular sodium and potassium in 26 patients with borderline arterial hypertension (BAH) and 41 patients with hypertensive disease, stage I (HD). It was shown that these patients revealed an essential(More)
Arterial pressure (AP) was monitored in 46 patients with arterial hypertension (AH) aged 18-50 years and in 33 healthy subjects living in Russian North (Tyumen Ob area, Nyagan). The comparison group consisted of 55 patients with AH and 33 healthy subjects living in a moderate climatic zone (Tyumen). The groups were comparable by gender, age, duration of AH,(More)
Chronostructure of arterial pressure (AP) and heart rate (HR) was studied in 62 residents of Tumen Region North with arterial hypertension (AH) aged 18-50 years and 56 AH controls living in the temperate zone. The groups were matched by age, sex, AH duration, office systolic and diastolic arterial pressure (SAP and DAP, respectively). Circadian AP profile(More)
Echocardiography and 24-hour BP monitoring were carried out in 177 men with stage 1 and 2 essential hypertension aged 25-59 years when they worked the Far North shift (group l) and in 75 patients with essential hypertension living in moderate climatic zone (group 2). Normal left ventricular geometry was found in 10 and 39% of subjects in groups l and 2,(More)