Ludmila Alekseeva

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BACKGROUND Aspergillus fumigatus, a saprophytic mould, is responsible for life-threatening, invasive pulmonary diseases in immunocompromised hosts. The role of the airway epithelium involves a complex interaction with the inhaled pathogen. Antimicrobial peptides with direct antifungal and chemotactic activities may boost antifungal immune response. (More)
Staphylococcus aureus is a highly versatile, opportunistic pathogen and the etiological agent of a wide range of infections in humans and warm-blooded animals. The epithelial surface is its principal site of colonization and infection. In this work, we investigated the cytopathic effect of S. aureus strains from human and animal origins and their ability to(More)
Aspergillus fumigatus, a ubiquitous fungus, is implicated in the pathogenesis of a number of clinically different allergic diseases in man. Peptide-based immunotherapy may offer an alternative in patient care and management. The purpose of this study was to evaluate the role of T cell epitopes of A. fumigatus ribotoxin, Asp f 1 in inducing tolerance in mice(More)
Maintenance of an intact epithelial barrier constitutes a pivotal defense mechanism against infections. Staphylococcus aureus is a versatile pathogen that produces multiple factors including exotoxins that promote tissue alterations. The aim of the present study is to investigate the cytopathic effect of staphylococcal exotoxins SEA, SEG, SEI, SElM, SElN(More)
Electron microscopic study of changes in cultured cells caused by Vibrio cholerae recombinant hemagglutinin/protease (HA/P) showed significant structural changes, most pronounced in HeLa and L-929 cells not forming a compact monolayer with tight junctions between the cells: formation of numerous vesicles on the cell surface and clasmatosis, vacuolation of(More)
Bioinformatics analysis of the primary and secondary structure of the Vibrio cholerae Cef (CHO cell elongating factor) protein was carried out. Similarity with triacylglycerol lipases and cytotonic toxins of other bacterial species was observed. Cef was predicted to be a heat-tolerant serine lipase with a Kunitz domain and leucine zipper. These data were(More)
Lithium oxybutyrate was studied for effects on the circadian pattern of reserpine-induced depression ("open field") in relation to the time of the drug use. Reserpine given in a single dose of 0.75 mg/kg caused a reduction of diurnal frequencies, inversion of rhythm acrophases, decrease in their mesors and amplitudes. Lithium oxybutyrate given after rhythm(More)
Intracaudate injections of lithium hydroxybutyrate (5 micrograms) produce a serotonin-like effect on the power characteristics of the caudatogram frequency ranges. However, when injected in a single dose, the drug is a serotonin antagonist at the level of the caudate nucleus. On the contrary, being administered for a long time, the drug potentiates the(More)
Lithium hydroxybutyrate (10 mg/kg) prevents the amphetamine-induced EEG arousal and amplitude frequency alterations in the motor and visual cortex, posterior hypothalamus, midbrain reticular formation, and caudate nucleus but potentiates the action of the psychostimulant on the EEG of the hippocamp and amygdala. The response to the light flickering rhythm(More)
No significant changes were recorded in the content of adrenalin or noradrenalin in the motor cortex, hippocampus, amygdala, thalamus, hypothalamus, mesencephalic reticular formation and caudate nucleus an hour after rabbits received a single injection of lithium hydroxybutyrate. The content of dopamine in the caudate nucleus rose, while that in the(More)