Lucy K. Mooney

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Even simple behaviour requires us to make decisions based on combining multiple pieces of learned and new information. Making such decisions requires both learning the optimal response to each given stimulus as well as combining probabilistic information from multiple stimuli before selecting a response. Computational theories of decision making predict(More)
INTRODUCTION Axial symptoms including postural instability, falls and failure of gait initiation are some of the most disabling motor symptoms of Parkinson's disease (PD). We performed bilateral deep brain stimulation (DBS) of the pedunculopontine nucleus (PPN) in combination with the caudal zona incerta (cZi) in order to determine their efficacy in(More)
INTRODUCTION The Pedunculopontine nucleus is a novel target for deep brain stimulation and this may improve postural instability and gait dysfunction in Parkinson's disease. If unilateral Pedunculopontine nucleus stimulation is as efficacious as bilateral stimulation this would lead to less surgical risk. METHODS 5 Parkinson's disease patients with(More)
INTRODUCTION Deep brain stimulation (DBS) can provide dramatic essential tremor (ET) relief, however no Class I evidence exists. MATERIALS AND METHODS Analysis methods: I) traditional cohort analysis; II) N-of-1 single patient randomised control trial and III) signal-to-noise (S/N) analysis. 20 DBS electrodes in ET patients were switched on and off for(More)
1 Department of Neurology, Institute of Clinical Neurosciences, University of Bristol and North Bristol NHS Trust, Bristol, BS16 1LE, UK 2 Department of Computer Science, University of Bristol, Bristol, BS8 1UB, UK 3 Department of Neurosurgery, Institute of Clinical Neurosciences, University of Bristol and North Bristol NHS Trust, Bristol, BS16 1LE 4(More)
1 Department of Neurology, Institute of Clinical Neurosciences, University of Bristol and North Bristol NHS Trust, Bristol, BS16 1LE, UK 2 Department of Computer Science, University of Bristol, Bristol, BS8 1UB, UK 3 Department of Neurosurgery, Institute of Clinical Neurosciences, University of Bristol and North Bristol NHS Trust, Bristol, BS16 1LE 4(More)
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