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Instituto de Biologia Experimental e Tecnológica, Apartado 12–2780–901 Oeiras, Portugal Instituto de Tecnologia Química e Biológica, Apartado 127–2780–901 Oeiras, Portugal Faculdade de Farmácia de Lisboa, Av. das Forças Armadas 1649–019 Lisboa, Portugal Estação Agronómica Nacional (INIAP), Quinta do Marquês, 2784–505 Oeiras, Portugal Universidade de Évora,(More)
Factor B is the central protease of the complement system of immune defense. Here, we present the crystal structure of human factor B at 2.3-A resolution, which reveals how the five-domain proenzyme is kept securely inactive. The canonical activation helix of the Von Willebrand factor A (VWA) domain is displaced by a helix from the preceding domain linker.(More)
Immune protection by the complement system critically depends on assembly of C3 convertases on the surface of pathogens and altered host cells. These short-lived protease complexes are formed through pro-convertases, which for the alternative pathway consist of the complement component C3b and the pro-enzyme factor B (FB). Here, we present the crystal(More)
Binding of von Willebrand Factor (vWF) to sites of vascular injury is the first step of hemostasis. Collagen types I and III are important binding sites for vWF. We have previously determined the three-dimensional structure of the collagen binding A3 domain of vWF (Huizinga et al., Structure 1997; 5: 1147). We hypothesized that the top face of this domain(More)
Sibipiruna (Caesalpinia peltophoroides Benth) is a tree of the Brazilian Atlantic Forest. It is a flowering ornamental tree widely planted throughout Brazil and indicated for restoration of degraded areas. We examined protein profile changes in leaves of seedlings of C. peltophoroides grown in nutrient solution under greenhouse conditions, after(More)
Protein S is a vitamin K-dependent plasma protein that functions as an APC-cofactor, but also exhibits anticoagulant activity in the absence of APC. The Heerlen polymorphism of protein S is characterized by a Ser460Pro substitution and lacks glycosylation at Asn458. It is associated with decreased protein S levels due to selective deficiency of free protein(More)
Thank you very much for submitting your research manuscript for consideration to The EMBO Journal editorial office. I received the comments of three scientists working on this topic that you will find enclosed for your information. Two of these clearly appreciate novelty and insight provided from the complex structure reported and have only minor comments(More)
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