Lucio Casali

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BACKGROUND The joint distribution of asthma and chronic obstructive pulmonary disease (COPD) has not been well described. This study aims at determining the prevalence of self-reported physician diagnoses of asthma, COPD and of the asthma-COPD overlap syndrome and to assess whether these conditions share a common set of risk factors. METHODS A screening(More)
The prevalence of asthma increased worldwide until the 1990s, but since then there has been no clear temporal pattern. The present study aimed to assess time trends in the prevalence of current asthma, asthma-like symptoms and allergic rhinitis in Italian adults from 1990 to 2010. The same screening questionnaire was administered by mail or phone to random(More)
The aim of our study was to measure values of maximal inspiratory (MIP) and expiratory (MEP) mouth pressures in 625 (266 male, 359 female) clinically and functionally normal subjects drawn out of a sample representative of the general population. MEP (near TLC and FRC) was found to be significantly higher when compared with MIP (near RV and FRC), and(More)
Platelets are necessary for lung leukocyte recruitment in a murine model of allergic inflammation, and platelet-leukocyte aggregates are formed in circulating blood of patients with asthma after allergen exposure. However, it is unknown how platelets induce pulmonary leukocyte recruitment in asthma. Here, we have investigated the importance of platelet(More)
Sarcoidosis is an immune-mediated, multiorgan, granulomatous disorder thought to be triggered by an intricate combination of environmental and genetic factors. Two robust lines of evidence support the hypothesis of a genetic component in the pathogenesis of sarcoidosis: racial variation in its epidemiology and familial clustering of cases. The relationship(More)
BACKGROUND No study has been carried out on the time trend in the prevalence of chronic bronchitis (CB) in recent years, despite its clinical and epidemiological relevance. We evaluated the trend in CB prevalence during the past decade among young Italian adults. METHODS A screening questionnaire was mailed to general population samples of 20-44 year-old(More)
In support of their belief that sarcoidosis mortality is higher in African-Americans than Caucasians, LUISETTI et al. [1] cited the GIDEON and MANNINO study [2] which reported a US sarcoidosis mortality ratio, African-American: Caucasian, of 14:1. The incidence rate ratio [3] has been estimated at 13:1. Thus, the differential mortality is attributable to a(More)
BACKGROUND Socioeconomic inequalities in smoking habits have stabilized in many Western countries. This study aimed at evaluating whether socioeconomic disparities in smoking habits are still enlarging in Italy and at comparing the impact of education and occupation. METHODS In the frame of the GEIRD study (Gene Environment Interactions in Respiratory(More)
The aetiology of sarcoidosis is still unknown. Environmental exposures are believed to interact with genetic factors in determining the pattern of sarcoidosis presentation, progression and prognosis. The frequency of serological polymorphism of immunoglobulin G heavy chain (Gm) and kappa light chain (kappam) markers in 107 patients with biopsy-proven(More)
In December 2009 an information sheet [1] edited by WHO reported that, in 2008, 3.6 million women fell ill with tuberculosis (TB) and 700,000 women died from TB, including 200,000 with human im-munodeficiency virus (HIV) and TB. TB is the 3 rd leading cause of death worldwide among women aged between 15 and 44 years. It should be noted that this range(More)