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We examined the contribution of the nigrostriatal DA system to instrumental learning and behavior using optogenetics in awake, behaving mice. Using Cre-inducible channelrhodopsin-2 (ChR2) in mice expressing Cre recombinase driven by the tyrosine hydroxylase promoter (Th-Cre), we tested whether selective stimulation of DA neurons in the substantia nigra pars(More)
885 of disorders, some of which can be treated (e.g., severe depression or effects of medications) but others of which may signal the development of incurable dementias, such as Alzheimer's disease. For these reasons, the development and improvement of diagnostic procedures — and neuroimaging procedures , in particular — that aid in characterizing cognitive(More)
2015 1 1 Acknowledgements I'd like to take this space to thank everyone who has supported and guided me through this. First and foremost, I'd like to thank Jonathan Winkle and Professor Scott Huettel, for not only helping me through all the tricky neuroscience bits of this particular thesis, but also for being a crucial part of my research experience here(More)
Hemosuccus pancreaticus is a rare cause of gastrointestinal bleeding from the duct of Wirsung into the duodenum via the ampulla of Vater. Hemosuccus pancreaticus is difficult to diagnose because the bleeding is usually intermittent, and the clinical findings are often discordant. Patients present with pain, either left upper quadrant or epigastric, and(More)
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