Lucie Rochard

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Regulation of convergence and extension by wnt-frizzled signaling is a common theme in embryogenesis. This study examines the functional requirements of frzb and fzd7a in convergence and extension mechanisms during craniofacial development. Using a morpholino knockdown approach, we found that frzb and fzd7a are dispensable for directed migration of the(More)
Holoprosencephaly (HPE), the most common developmental defect of the forebrain and midface, is caused by a failure of midline cleavage early in gestation. Isolated HPE, which is highly genetically heterogeneous, can be due to major chromosomal abnormalities. Initially, karyotype approach led to the identification of several recurrent chromosomal anomalies(More)
BACKGROUND Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is characterized by congenital aplasia of the uterus and the upper part of the vagina in women showing normal development of secondary sexual characteristics and a normal 46, XX karyotype. The uterovaginal aplasia is either isolated (type I) or more frequently associated with other malformations(More)
methodology and biological results obtained. Holoprosencephaly (HPE), the most common developmental defect of the forebrain, is caused by a failure to delineate the mid-line. HPE occurs in sporadic and inherited forms, and even HPE in pedigrees is characterized by variable expressivity. Point mutations and deletions were found in SHH, ZIC2, SIX3 and TGIF(More)
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