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BACKGROUND Although gestural communication is widespread in primates, few studies focused on the cognitive processes underlying gestures produced by monkeys. METHODOLOGY/PRINCIPAL FINDINGS The present study asked whether red-capped mangabeys (Cercocebus torquatus) trained to produce visually based requesting gestures modify their gestural behavior in(More)
We describe the design of a multicenter, randomized clinical trial to compare clinical, quality-of-life, and economic outcomes in patients with schizophrenia or schizoaffective disorder who were treated with risperidone or any of 13 conventional antipsychotic drugs approved for use in the United States. This 1-year trial was designed to approximate(More)
OBJECTIVE Four groups of patients receiving different antidepressant drugs in a primary care setting were compared in terms of duration of antidepressant therapy and health and mental health care utilization and costs. METHODS A retrospective analysis of the medical and pharmacy claims of an employed population and their families was conducted. A total of(More)
OBJECTIVE The effects of risperidone treatment on health care utilization and treatment costs were examined among patients with treatment-refractory schizophrenia or schizoaffective disorder. METHODS Data from the Santa Clara County Mental Health Department were used to measure inpatient and ambulatory services and outpatient medications related to the(More)
Specific overexpression in cancer cells and evidence of oncogenic functions make Survivin an attractive target in cancer therapy. The small molecule compound YM155 has been described as the first "Survivin suppressant" but molecular mechanisms involved in its biological activity and its clinical potential remain obscure. We herein show that YM155 exerts(More)
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