Luciano M. Melo

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Depression is the most frequent psychiatric disorder in Parkinson's disease (PD). Although evidence suggests that depression in PD is related to the degenerative process that underlies the disease, further studies are necessary to better understand the neural basis of depression in this population of patients. In order to investigate neuronal alterations(More)
The mechanisms underlying the effects of antidepressant treatment in patients with Parkinson's disease (PD) are unclear. The neural changes after successful therapy investigated by neuroimaging methods can give insights into the mechanisms of action related to a specific treatment choice. To study the mechanisms of neural modulation of repetitive(More)
Our goal was to estimate the diagnostic accuracy of substantia nigra fractional anisotropy (SN-FA) for Parkinson’s disease (PD) diagnosis in a sample similar to the clinical setting, including patients with essential tremor (ET) and healthy controls (HC). We also performed a systematic review and meta-analysis to estimate mean change in SN-FA induced by PD(More)
Among nonmotor symptoms observed in Parkinson's disease (PD) dysfunction in the visual system, including hallucinations, has a significant impact in their quality of life. To further explore the visual system in PD patients we designed two fMRI experiments comparing 18 healthy volunteers with 16 PD patients without visual complaints in two visual fMRI(More)
Background: Parkinson disease (PD) is a progressive illness of undetermined cause with characteristic motor findings that include rest tremor, rigidity, bradykinesia, and postural disturbance. But cognitive impairment is common even in nondemented. In addition PD has been associated with an increased risk of developing dementia. Objectives: This review(More)
This study had the objective to verify if the presence of wearing-off phenomenon in patients with Parkinson's disease (PD) could be better identified by the administration of the "Wearing-off Questionnaire Card" (QC). The participant patients were first evaluated by resident doctors in neurology and then invited to answer the QC for detection of motor and(More)
Papaya apical curl necrosis (PACN) has frequently been observed in several Brazilian states. Affected plants exhibit foliar chlorosis, curvature of the apex, shortening of the internodes leading to bunching of the crown leaves, necrosis of the young apical parts, leaf drop, and dieback. Naturally infected plants were sampled and subjected to PCR assays,(More)
An enzyme linked immunosorbent assay (ELISA) test and the classic agar gel immunodiffusion (AGID) test were used as diagnostic methods in the eradication of a focus of equine infectious anaemia from a herd of 86 horses. The ELISA test proved to be more sensitive, detecting positive animals earlier than the AGID test. A group of 16 animals positive only by(More)
AIM To compare the musculoskeletal (MSK) physical examination skills, knowledge acquisition and performance of first-year medical students trained by MSK specialist tutors to students trained by non-MSK specialist tutors, after a 6-week MSK physical examination tutorial program. METHODS Twenty-first year medical students took part in the study. They were(More)
Male, 26-years old, with acquired immunodeficiency syndrome which was admitted in the hospital with focal neurologic disturbance, developed myocardial failure and echocardiographic pattern of ventricular dysfunction. Sudden death occurred 18 days after admission and the post mortem microscopic studies showed degenerative abnormalities of cardiac muscular(More)