Lucia Mensikova

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OBJECTIVES Dihydropyridine calcium channel blockers have some disadvantages such as light sensitivity and relatively short plasma half-lives. Stability of dihydropyrimidines analogues could be of advantage, yet they remain less well characterized. We aimed to test four newly synthesized Biginelli-type dihydropyrimidines for their calcium channel blocking(More)
OBJECTIVE Epoxyeicosatrienoic acids (EETs) are a group of auto/paracrine mediators derived from arachidonic acid with vasculoprotective and vasodilatory properties. Hydroxyeicosatetraenoic acids (HETEs) act predominantly as physiological antagonists of EETs. Our objective was to compare expression of CYP enzymes involved in production and degradation of(More)
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