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Nuclear Entry of High-Risk Human Papillomavirus Type 16 E6 Oncoprotein Occurs via Several Pathways
TLDR
The data reveal that the HPV16 E6 oncoprotein interacts via its C-terminal NLS with several karyopherins and exploits these interactions to enter the nucleus of host cells via multiple pathways. Expand
Differentiation of Low-Attenuation Intracranial Hemorrhage and Calcification Using Dual-Energy Computed Tomography in a Phantom System
TLDR
Hemorrhagic and calcific lesions with attenuation levels between 50 and 100 HU were differentiable using DECT in a clinically relevant phantom system with higher than 90% accuracy. Expand
Optimizing Imaging of Three-Dimensional Multicellular Tumor Spheroids with Fluorescent Reporter Proteins Using Confocal Microscopy
TLDR
A series of optimizations were shown that allowed us to obtain excellent quality confocal microscopy images at imaging depths of up to 320 μm, extending the depth range beyond previously accepted limits. Expand
Molecular neuroimaging: the basics.
TLDR
This review, focusing on Molecular Neuroimaging, will show examples of such applications in the nervous system and successively deal with Receptors, Neurons, Stem Cells, Tumor Cells, Migroglia, Marker genes, Bioluminescence and Alzheimer related proteins. Expand
Hyperpolarized Pyruvate MR Spectroscopy Depicts Glycolytic Inhibition in a Mouse Model of Glioma.
TLDR
Hyperpolarized carbon 13 measurements of pyruvate metabolism can provide rapid feedback for monitoring treatment response in glioma. Expand
Axonal Transport as an In Vivo Biomarker for Retinal Neuropathy
TLDR
A fluorescent imaging agent based on the non-toxic C fragment of tetanus toxin (TTc) is devised, which is taken up and transported in neurons using the highly conserved fast axonal transport mechanism. Expand
Combinatorial targeting and discovery of ligand-receptors in organelles of mammalian cells
TLDR
Internalizing-phage libraries to identify clones that enter mammalian cells through a receptor-independent mechanism and target-specific organelles as a tool to select ligand peptides and identify their intracellular receptors are introduced. Expand
Fluorescence Imaging of Fast Retrograde Axonal Transport in Living Animals
TLDR
Neurography is demonstrated with a fluorescently labeled molecular imaging contrast agent based on the nontoxic C fragment of tetanus toxin (TTc), which could be labeled with fluorescent moieties without loss of immunoreactivity or biologic potency in cell uptake assays. Expand
Development of a Targeted Gene Vector Platform Based on Simian Adenovirus Serotype 24
TLDR
The development of an alternative vector platform using simian Ad serotype 24 (sAd24) is described, and it is found that sAd24 virions formed unstable complexes with blood coagulation factor X and, because of that, transduced the liver and other organs at low levels when administered intravenously. Expand
The Calcium Versus Hemorrhage Trial: Developing Diagnostic Criteria for Chronic Intracranial Susceptibility Lesions Using Single-Energy Computed Tomography, Dual-Energy Computed Tomography, and
TLDR
The updated criteria for the classification of chronic positive susceptibility brain lesions as hemorrhagic versus calcific for each major clinically available imaging modality are provided and should likely replace it as gold standard. Expand