Lucas J. van Vliet

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G. M. P. VAN KEMPEN,* L. J. VAN VLIET,* P. J. VERVEER† & H. T. M. VAN DER VOORT‡ *Pattern Recognition Group, Faculty of Applied Physics, Delft University of Technology, Lorentzweg 1, 2628 CJ Delft, The Netherlands †Department of Molecular Biology, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, D-37077 Göttingen, Germany ‡Scientific Volume(More)
Accurate modeling of image formation in cryo-electron microscopy is an important requirement for quantitative image interpretation and optimization of the data acquisition strategy. Here we present a forward model that accounts for the specimen's scattering properties, microscope optics, and detector response. The specimen interaction potential is(More)
Fluorescence in situ hybridization allows the enumeration of chromosomal abnormalities in interphase cell nuclei. This process is called dot counting. To estimate the distribution of chromosomes per cell, a large number of cells have to be analyzed, especially when the frequency of aberrant cells is low. Automation of dot counting is required because manual(More)
One of the essential ways in which nonlinear image restoration algorithms differ from linear, convolution-type image restoration filters is their capability to restrict the restoration result to nonnegative intensities. The iterative constrained Tikhonov-Miller (ICTM) algorithm, for example, incorporates the nonnegativity constraint by clipping all negative(More)
RATIONALE AND OBJECTIVES The aim of this study was to automatically detect and quantify calcium lesions for the whole heart as well as per coronary artery on non-contrast-enhanced cardiac computed tomographic images. MATERIALS AND METHODS Imaging data from 366 patients were randomly selected from patients who underwent computed tomographic calcium scoring(More)
The reconstruction problem in in-line X-ray Phase-Contrast Tomography is usually approached by solving two independent linearized sub-problems: phase retrieval and tomographic reconstruction. Both problems are often ill-posed and require the use of regularization techniques that lead to artifacts in the reconstructed image. We present a novel reconstruction(More)
An image processing algorithm is presented to reconstruct optical pathlength distributions from images of nonabsorbing weak phase objects, obtained by a differential interference contrast (DIC) microscope, equipped with a charge-coupled device camera. The method is demonstrated on DIC images of transparent latex spheres and unstained bovine spermatozoa. The(More)
The grading of inflammatory bowel disease (IBD) severity is important to determine the proper treatment strategy and to quantify the response to treatment. Traditionally, ileocolonoscopy is considered the reference standard for assessment of IBD. However, the procedure is invasive and requires extensive bowel preparation. Magnetic resonance imaging (MRI)(More)
OBJECTIVE The purpose of this article is to report the effect on lesion conspicuity and the practical efficiency of electronic cleansing for CT colonography (CTC). MATERIALS AND METHODS Patients were included from the Walter Reed Army Medical Center public database. All patients had undergone extensive bowel preparation with fecal tagging. A primary 3D(More)
OBJECTIVE The purpose of this study was to assess the accuracy and measurement variability of automated lesion measurement on CT colonography in comparison with manual 2D and 3D techniques under varying scanning conditions. MATERIALS AND METHODS The study included phantoms (23 phantom objects) and patients (16 polyps). Measurement with sliding calipers(More)