Luca Vassalli

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Previous studies have shown that propylene glycol causes inflammatory changes and cholesteatoma when applied to chinchilla middle ears. Vitamin A and synthetic analogues are essential for the normal differentiation of epithelial tissues. The purpose of this study was to determine whether the administration of isotretinoin to chinchillas would prevent(More)
This study examines the occurrence of inflammatory changes and cholesteatoma in the middle ears of seven chinchillas after the application of topical antibiotic suspensions containing two different concentrations of propylene glycol. The preparations used were Cortisporin otic suspension, which contains neomycin, polymyxin B, hydrocortisone, and 10.5%(More)
Labyrinthine destruction by direct cholesteatoma invasion has always been considered a serious threat to the inner ear function. A number of reports in the literature have cited both patients who had preservation of hearing despite widespread erosion of the labyrinth by cholesteatoma and patients who had retained auditory function despite surgical removal(More)
Intratemporal extensions of cerebellopontine angle (CPA) meningiomas are unusual and primary intratympanic meningiomas are extremely rare. The initial symptoms of both types are otologic. The presenting symptoms of even large meningiomas of the cerebellopontine angle can also be otologic. In this article we report the clinical features, diagnosis, and(More)
Propylene glycol is a solvent commonly used in topical otic preparations. This study examines the occurrence of inflammatory changes and cholesteatoma in chinchilla middle ears after the application of propylene glycol in varying concentrations. A total of 32 ears were studied, divided into four treatment groups. Three groups received propylene glycol in(More)
Unilateral progressive sensorineural hearing loss, tinnitus, and unsteadiness are the usual initial symptoms of acoustic neuroma. Of the last 100 consecutive cases of acoustic neuroma detected at our Centre, 14 had atypical symptoms, Five patients manifested sudden hearing loss; one of these had complete recovery. Three patients reported long-standing(More)
The site of the lesion in unilateral sensori-neural hearing loss (SNHL) may be confined to the receptor organ (labyrinthine) or may involve the auditory nerve including its central connections (retrolabyrinthine). The primary objective of the investigation of such a loss would be to define the probable site of the lesion. The protocol that we have found(More)
Background The problem of integrating different biomedical knowledge bases has to face lots of problems than are even more difficult in the biomedicine field. We moved from the need of the integration of KEGG and Reactome information in particular about the metabolic pathways. Since current systems like SRS, Kleisli and P/FDM cannot be used to integrate(More)
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