Luca Mazzarella

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Polycomb Repressor Complexes (PRCs) are important regulators of embryogenesis. In embryonic stem (ES) cells many genes that regulate subsequent stages in development are enriched at their promoters for PRC1, PRC2 and Ser 5-phosphorylated RNA Polymerase II (RNAP), and contain domains of 'bivalent' chromatin (enriched for H3K4me3; histone H3 di- or(More)
Modifications to the core histones are thought to contribute to ESC pluripotency by priming tissue-specific promoters and enhancers for later activation. However, it is unclear how these marks are targeted in ESCs and maintained during differentiation. Here, we show that the ESC factor Sox2 targets H3K4 methylation to monovalent and bivalent domains. In(More)
This paper extends the consensus framework, widely studied in the literature on distributed computing and control algorithms, to networks of quantum systems. We define consensus situations on the basis of invariance and symmetry properties, finding four different probabilistic generalizations of classical consensus states. We then extend the gossip(More)
At the cellular level, development progresses through successive regulatory states, each characterized by their specific gene expression profile. However, the molecular mechanisms regulating first the priming and then maintenance of gene expression within one developmental pathway are essentially unknown. The hematopoietic system represents a powerful(More)
Runx proteins are essential for hematopoiesis and play an important role in T cell development by regulating key target genes, such as CD4 and CD8 as well as lymphokine genes, during the specialization of naive CD4 T cells into distinct T helper subsets. In regulatory T (T reg) cells, the signature transcription factor Foxp3 interacts with and modulates the(More)
BACKGROUND Obesity is a major negative determinant of breast cancer outcome. However, there are contrasting data on the differential impact of obesity on specific breast cancer subtypes. In particular, very little is known on human epidermal growth factor receptor 2-positive (HER2+) tumours. PATIENTS AND METHODS We assessed the prognostic role of(More)
This paper interprets and generalizes consensus-type algorithms as switching dynamics leading to symmetrization with respect to the actions of a finite group. Explicit convergence results are provided in a grouptheoretic formulation, both for deterministic and for stochastic dynamics. We show how the symmetrization framework directly extends the scope of(More)
This paper extends the consensus framework, widely studied in the literature on distributed computing and control algorithms, to networks of quantum systems. We define consensus situations on the basis of invariance and symmetry properties, finding four different generalizations of classical consensus states. This new viewpoint can be directly used to study(More)
The association between obesity and/or metabolic syndrome and an elevated mortality from cancer has been confirmed by an astonishing number of studies across nations and ethnicities, such that obesity is now recognised to be among the most prominent cancer risk factors worldwide. Despite this overwhelming evidence and the societal impact of obesity, we know(More)