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Polycomb Repressor Complexes (PRCs) are important regulators of embryogenesis. In embryonic stem (ES) cells many genes that regulate subsequent stages in development are enriched at their promoters for PRC1, PRC2 and Ser 5-phosphorylated RNA Polymerase II (RNAP), and contain domains of 'bivalent' chromatin (enriched for H3K4me3; histone H3 di- or(More)
—This paper extends the consensus framework, widely studied in the literature on distributed computing and control algorithms, to networks of quantum systems. We define consensus situations on the basis of invariance and symmetry properties, finding four different probabilistic generalizations of classical consensus states. We then extend the gossip(More)
This paper interprets and generalizes consensus-type algorithms as switching dynamics leading to symmetriza-tion with respect to the actions of a finite group. Explicit convergence results are provided in a group-theoretic formulation, both for deterministic and for stochastic dynamics. We show how the symmetriza-tion framework directly extends the scope of(More)
At the cellular level, development progresses through successive regulatory states, each characterized by their specific gene expression profile. However, the molecular mechanisms regulating first the priming and then maintenance of gene expression within one developmental pathway are essentially unknown. The hematopoietic system represents a powerful(More)
Modifications to the core histones are thought to contribute to ESC pluripotency by priming tissue-specific promoters and enhancers for later activation. However, it is unclear how these marks are targeted in ESCs and maintained during differentiation. Here, we show that the ESC factor Sox2 targets H3K4 methylation to monovalent and bivalent domains. In(More)
BACKGROUND Despite current trend of targeted therapy development, cytotoxic agents are a mainstay of treatment of patients with breast cancer. We reviewed recent advances in cytotoxic therapy for patients with metastatic breast cancer (MBC). MATERIALS AND METHODS Medline searches were conducted for English language studies using the term 'MBC' and(More)
Runx proteins are essential for hematopoiesis and play an important role in T cell development by regulating key target genes, such as CD4 and CD8 as well as lymphokine genes, during the specialization of naive CD4 T cells into distinct T helper subsets. In regulatory T (T reg) cells, the signature transcription factor Foxp3 interacts with and modulates the(More)
—This paper extends the consensus framework, widely studied in the literature on distributed computing and control algorithms, to networks of quantum systems. We define consensus situations on the basis of invariance and symmetry properties, finding four different generalizations of classical consensus states. This new viewpoint can be directly used to(More)