Luca Mascitelli

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The objective was to provide the current state of the art regarding the role of vitamin D in chronic diseases (osteoporosis, cancer, cardiovascular diseases, dementia, autism, type 1 and type 2 diabetes mellitus, male and female fertility). The document was drawn up by panelists that provided their contribution according to their own scientific expertise.(More)
Current guidelines encourage ambitious long term cholesterol lowering with statins, in order to decrease cardiovascular disease events. However, by regulating the biosynthesis of cholesterol we potentially change the form and function of every cell membrane from the head to the toe. As research into cell morphology and membrane function realises more(More)
Götz et al. [1] analyzed common clinical and biochemical features between type 2 diabetes mellitus (T2DM) and Alzheimer’s disease (AD). However, among the suggested common pathogenic mechanisms between these disorders, they did not appear to mention the role of iron. Iron is a strong pro-oxidant which catalyzes several cellular reactions that yield reactive(More)
Do statins prevent or promote cancer? In their commentary, Drs. Takahashi and Nishibori 1 discuss putative antitumour effects of statins. However , prospective data suggest that statins actually increase cancer in certain segments of the population. Additionally, new findings regarding the immuno-modulatory effects of statins may explain the mechanism by(More)
OBJECTIVE It is well known that total cholesterol becomes less of a risk factor or not at all for all-cause and cardiovascular (CV) mortality with increasing age, but as little is known as to whether low-density lipoprotein cholesterol (LDL-C), one component of total cholesterol, is associated with mortality in the elderly, we decided to investigate this(More)
The metabolic syndrome (MetS) is manifested by a lipid triad which includes elevated serum triglycerides, small LDL particles, and low high-density lipoprotein (HDL) cholesterol, by central obesity (central adiposity), insulin resistance, glucose intolerance and elevated blood pressure, and it is associated with an increased risk of type 2 diabetes and(More)