Luca Leonardo Bologna

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Dissociated cortical neurons from rat embryos cultured onto micro-electrode arrays exhibit characteristic patterns of electrophysiological activity, ranging from isolated spikes in the first days of development to highly synchronized bursts after 3-4 weeks in vitro. In this work we analyzed these features by considering the approach proposed by the(More)
The intact brain is continuously targeted by a wealth of stimuli with distinct spatio-temporal patterns which modify, since the very beginning of development, the activity and the connectivity of neuronal networks. In this paper, we used dissociated neuronal cultures coupled to microelectrode arrays (MEAs) to study the response of cortical neuron assemblies(More)
Multi-channel acquisition from neuronal networks, either in vivo or in vitro, is becoming a standard in modern neuroscience in order to infer how cell assemblies communicate. In spite of the large diffusion of micro-electrode-array-based systems, researchers usually find it difficult to manage the huge quantity of data routinely recorded during the(More)
We present a neurorobotic framework to investigate tactile information processing at the early stages of the somatosensory pathway. We focus on spatiotemporal coding of first and second order responses to Braille stimulation, which offers a suitable protocol to investigate the neural bases of fine touch discrimination. First, we model Slow Adaptive type I(More)
OBJECTIVE Fine touch sensing relies on peripheral-to-central neurotransmission of somesthetic percepts, as well as on active motion policies shaping tactile exploration. This paper presents a novel neuroengineering framework for robotic applications based on the multistage processing of fine tactile information in the closed action-perception loop. (More)
Heparan sulfates (HSs) are complex and highly active molecules that are required for synaptogenesis and long-term potentiation. A deficit in HSs leads to autistic phenotype in mice. Here, we investigated the long-term effect of heparinase I, which digests highly sulfated HSs, on the spontaneous bioelectrical activity of neuronal networks in developing(More)
We present a neuro-inspired system for the investigation of fine dynamic haptic discrimination for neurorobotic and neuroprosthetic applications. A Braille reading task is adopted as case study. First, tactile inputs are encoded at the level of primary afferents mimicking human mechanoreceptors. Then, a network of simulated second-order neurones processes(More)
We present a closed-loop neurorobotic system to investigate haptic discrimination of Braille characters in a reading task. We first encode tactile stimuli into spiking activity of peripheral primary afferents, mimicking human mechanoreceptors. We then simulate a network of second-order neurones receiving the primary signals prior to their transmission to a(More)
  • Adam J. H. Newton, Alexandra H. Seidenstein, +497 authors David L. Boothe
  • BMC Neuroscience
  • 2017
© The Author(s) 2017. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the(More)
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