Luca Leonardo Bologna

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Dissociated cortical neurons from rat embryos cultured onto micro-electrode arrays exhibit characteristic patterns of electrophysiological activity, ranging from isolated spikes in the first days of development to highly synchronized bursts after 3-4 weeks in vitro. In this work we analyzed these features by considering the approach proposed by the(More)
Multi-channel acquisition from neuronal networks, either in vivo or in vitro, is becoming a standard in modern neuroscience in order to infer how cell assemblies communicate. In spite of the large diffusion of micro-electrode-array-based systems, researchers usually find it difficult to manage the huge quantity of data routinely recorded during the(More)
The intact brain is continuously targeted by a wealth of stimuli with distinct spatio-temporal patterns which modify, since the very beginning of development, the activity and the connectivity of neuronal networks. In this paper, we used dissociated neuronal cultures coupled to microelectrode arrays (MEAs) to study the response of cortical neuron assemblies(More)
— A framework to discriminate tactile stimuli delivered to an artificial touch sensor is presented. Following a neuromimetic approach, we encode the signals from a 24-capacitive sensor fingertip into spiking activity through a network of leaky integrate-and-fire neurons. The activity resulting from the stimulation of the touch sensor through Braille-like(More)
OBJECTIVE Fine touch sensing relies on peripheral-to-central neurotransmission of somesthetic percepts, as well as on active motion policies shaping tactile exploration. This paper presents a novel neuroengineering framework for robotic applications based on the multistage processing of fine tactile information in the closed action-perception loop. (More)
We present a neurorobotic framework to investigate tactile information processing at the early stages of the somatosensory pathway. We focus on spatiotemporal coding of first and second order responses to Braille stimulation, which offers a suitable protocol to investigate the neural bases of fine touch discrimination. First, we model Slow Adaptive type I(More)
Heparan sulfates (HSs) are complex and highly active molecules that are required for synaptogenesis and long-term potentiation. A deficit in HSs leads to autistic phenotype in mice. Here, we investigated the long-term effect of heparinase I, which digests highly sulfated HSs, on the spontaneous bioelectrical activity of neuronal networks in developing(More)
The quaternary structure of Molluscan hemocyanins is not still defined, in particular the spatial distribution and the structural subunits. It is important to establish the number and the nature of interations between functional units. Here we present two non-proteolytic methods for the depolymerization of hemocyanins. The results suggest that the(More)
BACKGROUND The increasing availability of different monoclonal antibodies (mAbs) opens the way to more specific biologic therapy of cancer patients. However, despite the significant success of therapy in breast and ovarian carcinomas with anti-HER2 mAbs as well as in non-Hodkin B cell lymphomas with anti-CD20 mAbs, certain B cell malignancies such as B(More)
We present a closed-loop neurorobotic system to investigate haptic discrimination of Braille characters in a reading task. We first encode tactile stimuli into spiking activity of peripheral primary afferents, mimicking human mechanoreceptors. We then simulate a network of second-order neurones receiving the primary signals prior to their transmission to a(More)
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