Luca Biasiolli

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BACKGROUND Ascending aortic dilation is important in bicuspid aortic valve (BAV) disease, with increased risk of aortic dissection. We used cardiovascular MR to understand the pathophysiology better by examining the links between 3-dimensional flow abnormalities, aortic function, and aortic dilation. METHODS AND RESULTS A total of 142 subjects underwent(More)
BACKGROUND Atherosclerotic plaques in carotid arteries can be characterized in-vivo by multicontrast cardiovascular magnetic resonance (CMR), which has been thoroughly validated with histology. However, the non-quantitative nature of multicontrast CMR and the need for extensive post-acquisition interpretation limit the widespread clinical application of(More)
BACKGROUND Evidence suggests that interleukin (IL)-1β is important in the pathogenesis of atherosclerosis and its complications and that inhibiting IL-1β may favorably affect vascular disease progression. OBJECTIVES The goal of this study was to evaluate the effects of IL-1β inhibition with canakinumab versus placebo on arterial structure and function,(More)
PURPOSE To prospectively compare the black-blood ( BB black blood ) imaging efficiency of a delay alternating with nutation for tailored excitation ( DANTE delay alternating with nutation for tailored excitation ) preparation module with conventional double inversion-recovery ( DIR double inversion recovery ) and motion-sensitive driven equilibrium ( MSDE(More)
BACKGROUND Restenosis of the carotid artery is common following carotid endarterectomy, but analysis of lesion composition has mostly been based on histological study of explanted restenotic lesions. This study investigated the ability of 3T cardiovascular magnetic resonance (CMR) to determine the components of recurrent carotid artery disease and examined(More)
Background Clinical studies that have measured plaque T2 times were mostly performed ex-vivo using a small number of plaques excised from different arterial locations and imaged at different field strength using a limited number of TEs. The Table shows that T2 measured in the lipidrich necrotic core (LRNC) was consistently shorter than T2 in fibrous tissue(More)
OBJECTIVES The goal of this study was to determine whether a 3-T magnetic resonance imaging (MRI) protocol combining carotid atherosclerotic plaque and brain imaging can identify features of high-risk acutely symptomatic plaque that correlate with brain injury. BACKGROUND It has previously been demonstrated that, in asymptomatic patients, MRI can identify(More)
Background DANTE (Delays Alternating with Nutation for Tailored Excitation) pulse trains are a rapid series of low flip angle RF pulses interspersed with gradients. We have previously demonstrated that when using DANTE pulse trains as a preparation module prior to imaging readout, the longitudinal magnetization of flowing spins is substantially attenuated,(More)
Background In-vivo carotid CMR is able to identify features of plaque vulnerability such as lipid core size. However, the current standard (multicontrast CMR) requires contrast media, extensive post-processing and subjective interpretation. Recently we proposed to use quantitative T2 mapping to distinguish plaque lipid from surrounding fibrous tissue and(More)
PURPOSE To test whether the k-space acquisition strategy used by fast-spin-echo (FSE) is a major source of blurring in carotid wall and plaque imaging, and investigate an alternative acquisition approach. MATERIALS AND METHODS The effect of echo train length (ETL) and T(2) on the amount of blurring was studied in FSE simulations of vessel images. Edge(More)