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- Régis Sablé-Fourtassou, Pascal Cohen, +11 authors Loïc Guillevin
- Annals of internal medicine
- 2005
BACKGROUND
Since testing for antineutrophil cytoplasmic antibodies (ANCA) became available for routine evaluation, no large homogeneous cohort of patients with the Churg-Strauss syndrome has been… (More)
- Éric Hachulla, Virginie Gressin, +13 authors Marc Humbert
- Arthritis and rheumatism
- 2005
OBJECTIVE
Screening allows for early management of pulmonary arterial hypertension (PAH), a severe complication of systemic sclerosis (SSc). Since no consensus has been reached on the method and… (More)
- Amal Ephrem, Souleima Chamat, +12 authors Namita Misra
- Blood
- 2008
The clinical use of intravenous immunoglobulin (IVIg) based on its immunomodulatory and anti-inflammatory potential remains an ongoing challenge. Fcgamma receptor-mediated effects of IVIg, although… (More)
- Christian Pagnoux, Alfred Mahr, +16 authors Löic Guillevin
- The New England journal of medicine
- 2008
BACKGROUND
Current standard therapy for Wegener's granulomatosis and microscopic polyangiitis combines corticosteroids and cyclophosphamide to induce remission, followed by a less toxic… (More)
The 1996 Five-Factor Score (FFS) for systemic necrotizing vasculitides (polyarteritis nodosa [PAN], microscopic polyangiitis [MPA], and Churg-Strauss syndrome [CSS]) is used to evaluate prognosis at… (More)
- Paul M Hassoun, Luc Mouthon, +14 authors Marc Humbert
- Journal of the American College of Cardiology
- 2009
Inflammatory processes are prominent in various types of human and experimental pulmonary hypertension (PH) and are increasingly recognized as major pathogenic components of pulmonary vascular… (More)
- Cloé Comarmond, Christian Pagnoux, +21 authors Loïc Guillevin
- Arthritis and rheumatism
- 2013
OBJECTIVE
Earlier studies of eosinophilic granulomatosis with polyangiitis (Churg-Strauss) (EGPA), with limited patient numbers and followup durations, demonstrated that clinical presentation at… (More)
- Amélie Servettaz, Claire Goulvestre, +8 authors Frédéric Batteux
- Journal of immunology
- 2009
Systemic sclerosis (SSc) is a connective tissue disorder of great clinical heterogeneity. Its pathophysiology remains unclear. Our aim was to evaluate the relative roles of reactive oxygen species… (More)
- Löic Guillevin, Christian Pagnoux, +22 authors Luc Mouthon
- The New England journal of medicine
- 2014
BACKGROUND
The combination of cyclophosphamide and glucocorticoids leads to remission in most patients with antineutrophil cytoplasm antibody (ANCA)-associated vasculitides. However, even when… (More)
- Bernard Piqueras, Cécile Lavenu-Bombled, +6 authors Eric Oksenhendler
- Journal of Clinical Immunology
- 2003
Common variable immunodeficiency (CVID) is a very heterogeneous syndrome defined by impaired immunoglobulin production. The functional classification of CVID patients on the basis of in vitro… (More)