Luc Legrès

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BACKGROUND Since microscopic slides can now be automatically digitized and integrated in the clinical workflow, quality assessment of Whole Slide Images (WSI) has become a crucial issue. We present a no-reference quality assessment method that has been thoroughly tested since 2010 and is under implementation in multiple sites, both public(More)
Background Since microscopic slides can now be automatically digitized and integrated in the clinical workflow, quality assessment of these Whole Slide Images (WSI) has become a crucial issue. At this time, the quality of a WSI is verified a posteriori by a technician or by a pathologist. There is however a significant amount of WSI that are too(More)
In advanced breast cancers, TP53 mutation is highly predictive of complete response to high-dose epirubicin/cyclophosphamide chemotherapy. In these tumours with an altered control of genomic stability, accumulation of chemotherapy-induced genetic alterations may contribute to cell death and account for complete response. To explore the effects of(More)
At this time, the quality of a Whole Slide Image (WSI) is verified a posteriori by a technician or a pathologist. A WSI of insufficient quality needs to be scanned again. High-speed automatic quality assessment tools for WSI will therefore greatly improve laboratory workflow. We describe here a fast method to automatically assess WSI quality, with different(More)
Functional heterogeneity in the lobule with regard to plasma protein synthesis is still debated. Therefore, we have localized in liver sections from normal rats and from rats with turpentine-induced AIR the mRNA and protein products of three genes with different alterations in their hepatic expression during an AIR: alpha 2M and alpha 1PI, two positively(More)
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