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We present the learning system Maccent which addresses the novel task of stochastic MAximum ENTropy modeling with Clausal Constraints. Maximum Entropy method is a Bayesian method based on the principle that the target stochastic model should be as uniform as possible, subject to known constraints. Maccent incorporates clausal constraints that are based on(More)
The discovery of the relationships between chemical structure and biological function is central to biological science and medicine. In this paper we apply data mining to the problem of predicting chemical carcino-genicity. This toxicology application was launched at IJCAI'97 as a research challenge for artificial intelligence. Our approach to the problem(More)
MOTIVATION Data Mining Prediction (DMP) is a novel approach to predicting protein functional class from sequence. DMP works even in the absence of a homologous protein of known function. We investigate the utility of different ways of representing protein sequence in DMP (residue frequencies, phylogeny, predicted structure) using the Escherichia coli genome(More)
The analysis of genomics data needs to become as automated as its generation. Here we present a novel data-mining approach to predicting protein functional class from sequence. This method is based on a combination of inductive logic programming clustering and rule learning. We demonstrate the effectiveness of this approach on the M. tuberculosis and E.(More)
The clausal discovery engine Claudien is presented. Claudien is an induc-tive logic programming engine that ts in the knowledge discovery in databases and data mining paradigm as it discovers regularities that are valid in data. As such Claudien performs a novel induction task, which is called characteristic induction from closed observations, and which is(More)
Inductive logic programming, or relational learning, is a powerful paradigm for machine learning or data mining. However, in order for ILP to become practically useful, the efficiency of ILP systems must improve substantially. To this end, the notion of a query pack is introduced: it structures sets of similar queries. Furthermore, a mechanism is described(More)