Luc Bergougnan

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Differential effects of omeprazole and pantoprazole on the pharmacodynamics and pharmacokinetics of clopidogrel in healthy subjects: randomized, placebo-controlled, crossover comparison studies.

Dominick Joseph Angiolillo, Christopher M Gibson, +7 authors Michel Dubar
Clinical pharmacology and therapeutics
2011

Four randomized, placebo-controlled, crossover studies were conducted among 282 healthy subjects to investigate whether an interaction exists between clopidogrel (300-mg loading dose/75-mg/day… (More)

Genetic polymorphisms and the impact of a higher clopidogrel dose regimen on active metabolite exposure and antiplatelet response in healthy subjects.

Tabassome Simon, Deepak L Bhatt, +7 authors Michel Dubar
Clinical pharmacology and therapeutics
2011

A double-blind crossover study was conducted in four CYP2C19 genotype-defined metabolizer groups to assess whether increase in clopidogrel dosing can overcome reduced pharmacodynamic response in… (More)

A review of the pharmacokinetics, tolerability and pharmacodynamics of amisulpride in healthy volunteers.

Pierre Rosenzweig, Muriel Canal, Alain A. Patat, Luc Bergougnan, I. Zieleniuk, Gabrio Bianchetti
Human psychopharmacology
2002

Amisulpride binds selectively to dopamine D(2) and D(3) receptors in the limbic system. Low doses of amisulpride preferentially block presynaptic D(2)/D(3)-dopamine autoreceptors, thereby enhancing… (More)

The acute effects of amisulpride (50 mg and 200 mg) and haloperidol (2 mg) on cognitive function in healthy elderly volunteers.

Eric Legangneux, John W. McEwen, +6 authors Pierre Rosenzweig
Journal of psychopharmacology
2000

In this double-blind, placebo controlled, four-way cross-over trial in 16 healthy elderly volunteers, the acute effects of haloperidol 2 mg, amisulpride 50 mg and 200 mg, were assessed on a range of… (More)

Modulation of vasoactivity and platelet aggregation by selective 5-HT receptor antagonism in humans.

M Moerland, Michiel J. B. Kemme, Anneke Corinne Dijkmans, Luc Bergougnan, Jacobus Burggraaf
Journal of cardiovascular pharmacology
2011

BACKGROUND Distinct serotonin [5-hydroxytryptamine (5-HT)] receptors are involved in platelet aggregation and vasoconstriction. Compounds that simultaneously and selectively inhibit the pertaining… (More)

PK‐PD relationship of the effects of argatroban on haemostasis in healthy young volunteers

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