Luana Ludwig

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We evaluated the efficacy of noninvasive mechanical ventilation (NIMV) in alleviating distress and avoiding intubation in patients with de novo acute respiratory failure complicating primary medical disorders. Eleven consecutive patients with severe respiratory distress were entered. In all patients a decision to intubate on an urgent basis had been made,(More)
The pharmacodynamic interaction between midazolam and the specific benzodiazepine antagonist Ro 15-1788 has been investigated in six healthy male volunteers. Hypnotic steady-state concentrations of midazolam (55 +/- 11 ng/mL; mean +/- SD) have been achieved rapidly by an intravenous bolus of 0.07 mg/kg and maintained by an individual but constant infusion(More)
In the past, pharmacokinetics of benzodiazepines have been extensively described. However, knowledge about relationships between their plasma levels and pharmacodynamic effects are scanty. Therefore, we investigated under several experimental conditions the disposition and the psychological response of the short acting midazolam (single dose 0,075 mg/kg(More)
BACKGROUND The immunologic function of the spleen and its important role in immune defense has led to splenic-preserving surgery. This study aimed to evaluate whether laparoscopic partial splenectomy is safe. METHODS Data on consecutive patients presenting with localized benign or malignant disease of the spleen were included in a prospective database.(More)
The beneficial effect of epinephrine has been attributed to its alpha-adrenergic properties. The present study was designed to compare the effects of epinephrine and methoxamine in witnessed cardiac arrests. Consecutive, witnessed cardiac-arrest victims presenting to the emergency room or from the inpatient population of our institution were enrolled in(More)
In a review of the experimental and clinical literature on nonvascularized and vascularized epiphyseal transfer, experience with eight patients with free vascularized fibular epiphyseal transfer suggests that transfer of bone with an open epiphysis offers some potential for growth in either congenital abnormalities or epiphyseal arrest secondary to trauma(More)
Alpha-tocopherol (2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-chromon-8-ol) is used in many previous urological studies. Thus to add to this knowledge in this study we studied the potential inhibitory activity on oxidative stress and process apoptosis on bladder wall in male rats subjected to androgen deprivation. A causal relationship between lower(More)
In 10 young, healthy male volunteers the stress-protective efficacy of bromazepam (orally 3 mg bid) was investigated double-blind (vs placebo) during steady state. Physical and mental stress was induced by ergometer (125 Watt for 5 minutes) and delayed auditory feedback, respectively. Stress response was measured biochemically (plasma concentrations of(More)