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OBJECTIVE To observe the effect of small dose donepezil (Aricept) on the cognition status and the changes of metabolites in brain tissue in patients with amnestic mild cognitive impairment (aMCI) in order to find out the effective way to prevent and cure dementia. METHODS 33 patients with aMCI were selected. There were 21 cases in a treatment group taking(More)
Three cases of Wernicke's encephalopathy in nonalcoholic patients diagnosed by postmortem examination were reported to improve the recognition of this disease. All three cases were male, ages ranged from 33 to 73 years old. All the cases had a clinical history of malnutrition but no history of chronic alcoholism. Routine autopsy and neuropathologic(More)
Due to increased awareness and interest in the biomedical implant field as a result of an aging population, research in the field of implantable devices has grown rapidly in the last few decades. Among the biomedical implants, metallic implant materials have been widely used to replace disordered bony tissues in orthopedic and orthodontic surgeries. The(More)
BACKGROUND Cattle encephalon glycoside and ignotin injection (CEGI), a multitargeted neurotrophic drug, has been widely used in the treatment of central and peripheral nerve injuries, such as stroke, hypoxic ischemic encephalopathy, and diabetic neuropathy in the People's Republic of China. However, data regarding the effect of CEGI on Alzheimer's disease(More)
BACKGROUND Physical activity is generally considered to be effective in reducing the prevalence of depression and promoting remission of its symptoms. However, large-scale epidemiological research on this issue is lacking in older Chinese adults. We performed a nationwide epidemiological survey to determine the relationship between physical activity and(More)
The beginning of Chinese neuro-pathology can be traced to the early years of the 20th century. In the 1920s to 1940s, a few neurologists from Beijing to Europe and the United States for training in clinical neuropathology (1). When they returned to China, they became the pioneers of Chinese neuropa-thology. In 1938, Drs. Hsu Yin-kuei and Cheng Yu-lin(More)
Progressive supranuclear palsy (PSP) is an atypical parkinsonism, which is the third most common geriatric neurodegenerative disease. We reported three pathology-confirmed Chinese PSP cases with special focus on the pathological accumulations of tau, a-synuclein and A-beta in the three PSP brains. Cases 1 and 2 initiated with extrapyramidal signs and gait(More)
Bilateral cerebral hemorrhages in the medial areas of bilateral putamens that impair the memory and calculation abilities are rare clinical entities. In the case presently reported, the patient suffered initial cerebral hemorrhage 3 years ago in the medial area of putamen on the right side with light left paralysis but the learning and memory functions were(More)
von Economo neuron (VEN) is a bipolar neuron characterized by a large spindle-shaped soma. VEN is generally distributed in the layer V of anterior insular lobe and anterior cingulate cortex. Fork neuron is another featured bipolar neuron. In recent years,many studies have illustrated that VEN and fork neurons are correlated with complicated cognition such(More)