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Patterns of gene expression in the central nervous system are highly variable and heritable. This genetic variation among normal individuals leads to considerable structural, functional and behavioral differences. We devised a general approach to dissect genetic networks systematically across biological scale, from base pairs to behavior, using a reference(More)
This paper investigates the problem of Partitioning Skew in MapReduce-based system. Our studies with Hadoop, a widely used MapReduce implementation, demonstrate that the presence of partitioning skew causes a huge amount of data transfer during the shuffle phase and leads to significant unfairness on the reduce input among different data nodes. As a result,(More)
Massive multiple-input multiple-output (MIMO) wireless communications refers to the idea equipping cellular base stations (BSs) with a very large number of antennas, and has been shown to potentially allow for orders of magnitude improvement in spectral and energy efficiency using relatively simple (linear) processing. In this paper, we present a(More)
Recombinant inbred (RI) strains of mice are an important resource used to map and analyze complex traits. They have proved particularly effective in multidisciplinary genetic studies. Widespread use of RI strains has been hampered by their modest numbers and by the difficulty of combining results derived from different RI sets. We have increased the density(More)
We combined large-scale mRNA expression analysis and gene mapping to identify genes and loci that control hematopoietic stem cell (HSC) function. We measured mRNA expression levels in purified HSCs isolated from a panel of densely genotyped recombinant inbred mouse strains. We mapped quantitative trait loci (QTLs) associated with variation in expression of(More)
Recombinant inbred (RI) strains are an important resource for mapping complex traits in many species. While large RI panels are available for Arabidopsis, maize, C. elegans, and Drosophila, mouse RI panels typically consist of fewer than 30 lines. This is a severe constraint on the power and precision of mapping efforts and greatly hampers analysis of(More)
and D, have both been sequenced and are known to differ at roughly 1.8 million singlenucleotide polymorphisms (SNPs) across the mouse genome. This amounts to an average of one SNP every 1,500 base pairs. Each of the BXD strains is a unique ‘mosaic’ of chromosomal segments inherited from either the B or D progenitor strain4. About 34 BXD strains are(More)
Renewable H(2) production from a plentiful biomass, waste activated sludge (WAS), can be achieved by fermentation, but the yields are low. The use of a microbial electrolysis cell (MEC) can increase the H(2) production yields to several times that of fermentation. We have proved that the enhancement of H(2) production was due to the ability of MECs to use a(More)
The concept of physical-layer network coding (PNC) was proposed in 2006 for application in wireless networks. Since then it has developed into a subfield of network coding with wide followings. The basic idea of PNC is to exploit the network coding operation that occurs naturally when electromagnetic (EM) waves are superimposed on one another. This simple(More)