Luísa Castro

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—An agglomerative hierarchical clustering method, which uses both spectral and spatial information for the aggrega-tion decision, is proposed here. The method is suitable for large multispectral images, provided that an unsupervised classification is previously applied. The method is tested on a synthetic image and on a satellite image of the coastal zone.
Phase precession is one of the most well known examples within the temporal coding hypothesis. Here we present a biophysical spiking model for phase precession in hippocampal CA1 which focuses on the interaction between place cells and local inhibitory interneurons. The model’s functional block is composed of a place cell (PC) connected with a local(More)
Nicotinamide phosphoribosyltransferase (NAMPT) and nicotinate phosphoribosyltransferase domain containing 1 (NAPRT1) are the main human NAD salvage enzymes. NAD regulates energy metabolism and cell signaling, and the enzymes that control NAD availability are linked to pathologies such as cancer and neurodegeneration. Here, we have screened normal and tumor(More)
Grid cells (GCs) in the medial entorhinal cortex (mEC) have the property of having their firing activity spatially tuned to a regular triangular lattice. Several theoretical models for grid field formation have been proposed, but most assume that place cells (PCs) are a product of the grid cell system. There is, however, an alternative possibility that is(More)
MOTIVATION Ebola virus causes high mortality hemorrhagic fevers, with more than 25 000 cases and 10 000 deaths in the current outbreak. Only experimental therapies are available, thus, novel diagnosis tools and druggable targets are needed. RESULTS Analysis of Ebola virus genomes from the current outbreak reveals the presence of short DNA sequences that(More)
Nicotinamide Adenine Dinucleotide (NAD) levels are essential for cellular homeostasis and survival. Main sources of intracellular NAD are the salvage pathways from nicotinamide, where Nicotinamide phosphoribosyltransferases (NAMPTs) and Nicotinamidases (PNCs) have a key role. NAMPTs and PNCs are important in aging, infection and disease conditions such as(More)
Grid cells in the medial entorhinal cortex (mEC) encode space in a particular way: their firing rate intensity forms an equilateral triangular lattice as the animal moves in the environment [1]. Models addressing the generation of grid fields fall into two major classes, both with important limitations [2]. Most models based on interference of oscillations(More)
Coding information in the hippocampus through phase-precession means that the phase in the theta cycle in which a place cell fires provides information regarding the position of the rat in the place field. There are published models addressing the phase-precession effect but commonly they are grounded in stringent assumptions or ignore the fact that signals(More)
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