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A reproducible method for the successful silica coating of silver nanoparticles is reported. A selection of tri-functional reporter molecules were designed to allow controlled synthesis of silica shelled, dye coded, SERS active silver nanoparticles.
The ability to detect chirality gives stereochemically attuned nanosensors the potential to revolutionize the study of biomolecular processes. Such devices may structurally characterize the mechanisms of protein-ligand binding, the intermediates of amyloidogenic diseases and the effects of phosphorylation and glycosylation. We demonstrate that single… (More)