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We have developed a monoclonal antibody (4A7) directed against the C-terminus of the ataxin-2 protein that is involved in the polyglutamine neurodegenerative disorder spinocerebellar ataxia type 2. Comparison with other ataxin-2 antibodies showed that 4A7 specifically recognized ataxin-2. In contrast, a previously reported ataxin-2 antibody (15F6) did not(More)
The authors studied inclusion formation in vitro using transiently transfected PC12 cells, with epitope-tagged and untagged full-length and truncated wild-type and expanded ataxins -1, -2, -3, and -7. At 72 hours, no inclusions were seen with wild-type full-length or truncated ataxins -2, -3, or -7, and only one with ataxin-1. Truncation abolished nuclear(More)
The main aim of this thesis is to provide insight into the interaction of the syntactic and pragmatic properties of German, particularly with respect to the issue of con-gurationality. This language is particularly diicult to classify as it displays both subject-object asymmetries (a feature of \conngurational" languages), but also has a topic position (a(More)
Executive summary Rabies is a zoonotic viral disease that causes acute encephalitis in humans and other warm-blooded animals; it is the only disease with almost 100% mortality once clinical signs are present. Transmission is usually through saliva via the bite of an infected animal, with dogs being the main transmitter of rabies to humans. The World Health(More)
Recently, it has been suggested that anti-gliadin antibodies (αGAb) may produce “gluten ataxia”, even in the absence of celiac disease enteropathy. αGAb are reportedly present in 12–50 % of patients with sporadic ataxia, but also in 12 % of the general population, such that the importance of αGAb as a cause of sporadic ataxia is not conclusively settled. We(More)
Most adult-onset sporadic ataxias are unexplained, and the claim that many of these may be a result of gluten sensitivity has led to uncertainty as to whether to test for anti-gliadin antibodies (αGAb) and, if present, whether to recommend a gluten-free diet or continue searching for other causes of ataxia. This uncertainty arises in part from the frequency(More)
In this article the development and parameterization of a quantitative assessment is described that estimates the amount of TSE infectivity that is present in a whole animal carcass (bovine spongiform encephalopathy [BSE] for cattle and classical/atypical scrapie for sheep and lambs) and the amounts that subsequently fall to the floor during processing at(More)
A qualitative exposure assessment for Salmonella in eggs produced on the island of Ireland was developed. The assessment was divided into three main modules (production and packing, distribution and storage, and preparation and consumption), and each of these stages into defined steps in the exposure pathway. In the production and packing stage the initial(More)
This paper is based on a recent research grant proposal submitted to ESRC en-titled`A cross-linguistic investigation into the impairment of functional categories in agrammatism in English and Scots Gaelic'. We outline a theoretically-motivated approach for characterising agrammatism, an acquired language deecit associated with Broca's aphasia. Based on(More)
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