Louise Fleming

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Patients with severe refractory asthma pose a major healthcare problem. Over the last decade it has become increasingly clear that, for the development of new targeted therapies, there is an urgent need for further characterisation and classification of these patients. The Unbiased Biomarkers for the Prediction of Respiratory Disease Outcomes (U-BIOPRED)(More)
T he patient, a two-month-old Gambian infant, was one of twins born in November 2003. In the latter part of her pregnancy, the patient's mother went to stay with her family in southern Senegal, where she delivered at uncertain gestation in a village health centre. The patient, a 1.75-kg girl, and her sibling, a 2.4-kg boy, were both born alive. Soon after(More)
BACKGROUND Previous studies in adults with asthma incorporating the control of sputum eosinophils into management strategies have shown significant reductions in exacerbations. A study was undertaken to investigate whether this strategy would be successful in children with severe asthma. METHODS 55 children (7-17 years) with severe asthma were randomised(More)
BACKGROUND The mechanism underlying severe asthma with fungal sensitization (SAFS) is unknown. IL-33 is important in fungus-induced asthma exacerbations, but its role in fungal sensitization is unexplored. OBJECTIVE We sought to determine whether fungal sensitization in children with severe therapy-resistant asthma is mediated by IL-33. METHODS(More)
T he patient, a two-month-old Gambian infant, was one of twins born in November 2003. In the latter part of her pregnancy, the patient's mother went to stay with her family in southern Senegal, where she delivered at uncertain gestation in a village health centre. The patient, a 1.75-kg girl, and her sibling, a 2.4-kg boy, were both born alive. Soon after(More)
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