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An active process within the cochlea is necessary to obtain the sensitivity and frequency selectivity characteristic of mammalian hearing. This process is realized, at least in part, through the electromotile response of outer hair cells (OHCs). Electromotility requires the presence of prestin, a transmembrane protein highly expressed in the OHC lateral(More)
The transmembrane protein prestin is crucial to outer hair cell (OHC) electromotility and contributes to the sensitivity and frequency selectivity of mammalian hearing. The molecular mechanisms of electromotility remain unclear, but prestin is purported to function as both a voltage sensor and a molecular motor. Understanding the role of prestin requires(More)
The outer hair cell (OHC) lateral plasma membrane houses the transmembrane protein prestin, a necessary component of the yet unknown molecular mechanism(s) underlying electromotility and the exquisite sensitivity and frequency selectivity of mammalian hearing. The importance of the plasma membrane environment in modulating OHC electromotility has been(More)
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