Louise E McGreavey

Learn More
Summary:The factors affecting T cell reconstitution post haematopoietic cell transplantation (HCT) are not well characterised. We carried out a longitudinal analysis of T cell reconstitution in 32 HCT recipients during the first 12 months post transplant. We analysed reconstitution of naïve, memory and effector T cells, their diversity and monitored thymic(More)
OBJECTIVES Regular continuous non-steroidal anti-inflammatory drug (NSAID) use has been associated with a reduction in risk of colorectal cancer. Our objective was to investigate whether or not a number of the polymorphic genes involved in the metabolism of NSAIDs, including cytochrome P450 s (CYPs), act as modifiers of this protective effect. METHODS As(More)
Although the occurrence of both chromosomal aberrations and specific gene mutations in colorectal tumorigenesis is firmly established, the relationship between these different forms of genetic abnormality remains poorly understood. We have previously demonstrated, in colorectal adenocarcinomas, that mutations of APC, KRAS, and TP53 are each specifically(More)
Summary:The study of thymic-dependent pathways of T cell reconstitution in T cell replete haematopoietic cell transplant (HCT) recipients in previous studies was complicated by the transfer of naïve CD4+CD45RA+ T cells with the stem cell graft. However, direct quantification of thymic output has been enabled by measurement of T cell receptor excision(More)
Nancy Andrews Debra R. Ayres Andrew Beckenbach Jeffrey L. Brodsky Richard P. Brown Christopher Burridge Mair E. A. Churchill Christopher T. Cole Surangi Dharmawardhane Lisa Davis Robert T. Dillon Walter W. Dimmick Jonathan Drachman William Duax William Heed David W. Hein Anna Himler Arne Holmgren Howard J. Jacob Mehdi Kabani Karl T. Kelsey Damase Khasa(More)
  • 1