Louis T J Delbaere

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Tuberculosis (TB) is a major public health problem with one-third of the world's population infected by its etio-logic agent, Mycobacterium tuberculosis, and over two million people dying from the disease each year. Improvement of the current treatment requires the development of more potent therapeutic agents that could act on latent and persistent bacilli(More)
Thermotoga maritima TM0298 is annotated as an alcohol dehydrogenase, yet it shows high identity and similarity to mesophilic mannitol dehydrogenases. To investigate this enzyme further, its gene was cloned and expressed in Escherichia coli. The purified recombinant enzyme was most active on fructose and mannitol, making it the first known hyperthermophilic(More)
Phosphoenolpyruvate carboxykinase (PCK) catalyzes the conversion of oxaloacetate to phosphoenolpyruvate and carbon dioxide with the subsequent conversion of nucleoside triphosphate to nucleoside diphosphate. This reaction is the first committed step of gluconeogenesis in all organisms. A divalent metal cation, such as Mg 2+ or Mn 2+ , is also required for(More)
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