Louis Shuster

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of these receptors may lower dopamine content in the brain and increase the size of the striatum as seen in experimental animals and humans treated chronically with neuroleptics. As previously proposed, a hypodopaminergic state may also mediate the increase in the size of the striatum seen in chronic drug users. In conclusion, our findings highlight the(More)
Mice exposed to repeated attacks by other mice showed decreased nociception in response to radiant heat focused on their tails. This form of analgesia was blocked by centrally acting opiate antagonists and was not observed in morphine-tolerant mice; furthermore, mice repeatedly subjected to defeat. Mice of the CXBK strain, which respond weakly to morphine,(More)
Repeated administration of cocaine to B6AF1/J mice increased their running response to 20 mg/kg cocaine as much as four-fold over the response to the first injection. After four daily injections, the extent of the increase was proportional to the dose of cocaine that was used for pretreatment. Sensitization persisted for as long as 2 months after the last(More)
The running response of B6AF1/J mice to 25 mg/kg of morphine sulfate was increased up to 3-fold when this dose was administered either twice daily for 5 days or once a week for 2 or 3 weeks. The effect of weekly pretreatment was proportional to the dose of morphine and lasted as long as 1 month after pretreatment was stopped. There was no sensitization when(More)
Chronic cocaine administration has been associated with sensitization (an increase in drug effect) rather than the tolerance observed with many psychotropic compounds. Because cocaine acts at the presynaptic dopamine transporter, we evaluated sensitization and striatal dopamine transporter binding in vivo in several mouse strains. All strains of mice(More)
Two progenitor strains, BALB/cBy and C57BL/6By, their reciprocal F1 hybrids, and seven of their recombinant-inbred derived lines were used to examine the genetic basis of the response to thermal pain, and morphine analgesia at doses of 2.5, 5.0 and 10.0 mg/kg. Both the latency of response to thermal pain and the analgesic response differed significantly(More)
OBJECTIVE To evaluate fluoxetine for the treatment of owner-directed dominance aggression in dogs. DESIGN Prospective study. ANIMALS 9 dogs of various breeds, ages, and either sex determined to have owner-directed dominance aggression. PROCEDURE Placebo and fluoxetine (1 mg/kg of body weight) were compared for the treatment of owner-directed dominance(More)