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BACKGROUND Renal cell carcinoma is a common malignancy that often presents as a metastatic-disease for which there are no effective treatments. To gain insights into the mechanism of renal cell carcinogenesis, a number of genome-wide expression profiling studies have been performed. Surprisingly, there is very poor agreement among these studies as to which(More)
BACKGROUND MicroRNA regulate mRNA levels in a tissue specific way, either by inducing degradation of the transcript or by inhibiting translation or transcription. Putative mRNA targets of microRNA identified from seed sequence matches are available in many databases. However, such matches have a high false positive rate and cannot identify tissue(More)
BACKGROUND Renal cell carcinoma (RCC) is the most common cancer in adult kidney. The accuracy of current diagnosis and prognosis of the disease and the effectiveness of the treatment for the disease are limited by the poor understanding of the disease at the molecular level. To better understand the genetics and biology of RCC, we profiled the expression of(More)
Microarray gene expression profiles of both renal cell carcinoma (RCC) tissues and a RCC cell line were analyzed using singular value decomposition (SVD) and functional clustering. The SVD projections of the expression profiles revealed significant differences between the profiles of RCC tissues and a RCC cell line. Based on the biological processes ,(More)
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