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There are very few drugs that prevent the relapse of Plasmodium vivax malaria in man. Tinidazole is a 5-nitroimidazole approved in the USA for the treatment of indications including amoebiasis and giardiasis. In the non-human primate relapsing Plasmodium cynomolgi/macaque malaria model, tinidazole cured one of six macaques studied with an apparent mild(More)
  • Gregory A Deye, R Scott Miller, +10 authors Alan J Magill
  • 2012
BACKGROUND We conducted a randomized, placebo-controlled, double-blind trial to establish the efficacy of atovaquone-proguanil to prevent malaria with the goal of simulating weekly dosing in a human Plasmodium falciparum challenge model. METHODS Thirty volunteers randomly received 1 of the following dose regimens: (1) 250 milligrams of atovaquone and 100(More)
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