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T follicular helper cells (Tfh cells) localize to follicles where they provide growth and selection signals to mutated germinal center (GC) B cells, thus promoting their differentiation into high affinity long-lived plasma cells and memory B cells. T-dependent B cell differentiation also occurs extrafollicularly, giving rise to unmutated plasma cells that(More)
We have previously shown that monoclonal antibody E12 (MAb E12), one of several such antibodies raised against theophylline-treated Necturus gallbladder (NGB) epithelial cells, inhibits the chloride conductance in the apical membrane of that tissue. Since chloride channels are critical to the secretory function of epithelia in many different animals, we(More)
Abnormal extracellular accumulation of beta-amyloid (Abeta), the major component of senile plaques in the Alzheimer's brain and the excitatory amino acid glutamate are both considered to be associated with neurodegeneration. We studied whether nitric oxide (NO) was involved in neuronal damage induced by Abeta and glutamate in primary rat cortical neurons.(More)
Our previous experiments demonstrated that lesions in the anteroventral third ventricle (AV3V) region of the brain attenuated natriuretic and diuretic response to saline loading in rats. To further assess if renal nerves are involved in this impaired response, we compared the effect of acute unilateral renal denervation on the response to saline loading in(More)
The immunological and cellular properties of cultured normal and fetal brain cells as well as glioma cells were compared. They were grown successfully in tissue culture media. Results from the growth properties and karyotype analysis indicated that cultured cells from normal and fetal brain tissues were normal and could be passaged limited times. The fetal(More)
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