Louis Lippiello

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Since 1960, numerous studies have supported the thesis that the synthetic activity of articular chondrocytes is increased in osteoarthritis, but several recent reports have challenged this concept. To clarify this problem fully and also to define further the products of this increased synthesis, three experiments were performed in which the distribution and(More)
Tissues from sixty-nine cartilage tumors in sixty-six individuals were obtained at the time of operation and each lesion was graded as benign (seventeen) or as a low-grade (thirty-three) or high-grade (nineteen) chondrosarcoma according to histological and roentgenographic criteria. The material obtained was analyzed by biochemical techniques for its(More)
The cartilages from the hip joints of 13 normal and 15 osteoarthritic humans were analyzed for glycosaminoglycan content and distribution. The GAGs were separated by elution with CPC on a short cellulose column by the technique of Svejcar and Robertson after digestion of the tissue with pronase and papain. The eluates were identified by a variety of methods(More)
The etiology of the unicameral bone cyst remains undefined. Likewise, the treatment of the cyst has had proponents suggesting procedures ranging from decompression to diaphyseal resection. The use of intralesional steroids has gained popularity since its introduction in 1979 by Scaglietti. We present the results of aspirations of seven cysts, with serial(More)
Fluorescein isothiocyanate-conjugated sheep antirabbit gamma-globulin was used in the indirect fluorescent antibody technique to localize the vitamin D-dependent calcium-binding protein (CaBP) in the shell gland of the laying hen. Intense specific fluorescence, indicative of the presence of CaBP, was found only in the tubular gland cells and not in the(More)
Short term incubations of articular cartilage in media from cultures of rheumatoid synovial tissue result in marked inhibition of 3H-glycine and Na235SO4 incorporation into trichloroacetic acid (TCA) insoluble macromolecules by the cartilage segments with little effect on degradation of prelabeled cartilage matrix. This inhibition is time dependent and not(More)
Supplements of glucosamine hydrochloride, low molecular weight chondroitin sulfate, and manganese ascorbate were tested separately and in combination for their ability to retard progression of cartilage degeneration in a rabbit instability model of osteoarthrosis. Computerized quantitative histologic evaluation of safranin O stained sections of the medial(More)