Louis A. Schmidt

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Four-month-old infants were screened (N = 433) for temperamental patterns thought to predict behavioral inhibition, including motor reactivity and the expression of negative affect. Those selected (N = 153) were assessed at multiple age points across the first 4 years of life for behavioral signs of inhibition as well as psychophysiological markers of(More)
Previous research has shown that infants who display a high frequency of motor activity and negative affect at 4 months of age are likely to be behaviorally inhibited toddlers. We examined social behaviors, maternal report of temperament, salivary cortisol, and baseline startle responses at age 4 in a sample of children, some of whom displayed a high(More)
The error-related negativity (ERN or Ne) and positivity (Pe) are event-related potential components elicited during simple discrimination tasks after an error response. The ERN and Pe have a fronto-central scalp distribution and may be an indirect measure of anterior cingulate (AC) activity as it relates to performance monitoring. Brain imaging studies(More)
Gene-environment interactions are presumed to shape human behavior during early development. However, no human research has demonstrated that such interactions lead to stable individual differences in fear responses. We tested this possibility by focusing on a polymorphism in the promoter region of the gene for the serotonin transporter (5-HTT). This(More)
The present study investigated electrocortical and cardiovascular reactivity during positive and negative emotion, and examined the relation of asymmetric frontal lobe activation to cardiovascular responses. Participants were 30 healthy, right-handed university students (mean age, 23.9; 60% female; 76% Caucasian). Electroencephalographic (EEG), blood(More)
Affective perception has been suggested to involve the coordinated activation of widely distributed cortical networks, including those involved in sensory storage/analysis and higher-order structures, such as the prefrontal cortex that regulate these processes. We measured regional electroencephalogram (EEG) activity while young adult participants viewed(More)
We examined differences in brain electrical activity (EEG), heart rate (EKG), heart rate variability, and behavior among 40 young women who were selected for high (HI) and low (LO) self-ratings of shyness and sociability. EEG and EKG were continuously recorded for 6 min from each subject, just prior to an expected novel social encounter. Each subject was(More)
We examined temporal changes in behavior, regional brain electrical activity (EEG), heart rate, cardiac vagal tone, the startle eyeblink response, and salivary cortisol during a task designed to elicit self-presentation anxiety in a group of 7-year-olds, some of whom were classified as temperamentally shy. We found that temperamentally shy children(More)
OBJECTIVE Although distinct patterns of resting brain electrical activity (EEG) and functional connectivity are believed to distinguish individuals with autism spectrum disorders (ASD) from their unimpaired peers, researchers have only recently begun to link patterns of brain activity and connectivity to behavior in ASD. METHOD We examined regional(More)
Coupling between EEG delta and beta oscillations is enhanced among anxious and healthy individuals during anticipatory anxiety. EEG coupling patterns associated with psychotherapy have not yet been quantified in socially anxious individuals. In this study, we used a double baseline, repeated measures design, in which 25 adults with a principal diagnosis of(More)