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Lymphomas arising from NK or γδ-T cells are very aggressive diseases and little is known regarding their pathogenesis. Here we report frequent activating mutations of STAT3 and STAT5B in NK/T-cell… (More)
Follicular lymphoma (FL) is typically an indolent disease, but 30–40% of FL cases transform into an aggressive lymphoma (tFL) with a poor prognosis. To identify the genetic changes that drive this… (More)
Pharmacological agents that inhibit enzymes of the B-cell receptor (BCR) pathway are of increasing importance in the treatment of B-cell malignancies. These include inhibitors of Bruton tyrosine… (More)
Can Küçük1,*, Bei Jiang1,*, Xiaozhou Hu1, Wenyan Zhang2, John K.C. Chan3, Wenming Xiao4, Nathan Lack5, Can Alkan6, John C. Williams7, Kendra N. Avery7, Pınar Kavak8, Anna Scuto1, Emel Sen5, Philippe… (More)
Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA Introduction: Preliminary data show that up to 10% of patients on early clinical trials have complete (CR) or partial… (More)