Lotta Pollak

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The mu-opioid receptor (MOR), through its effects on reward and stress-responsivity, modulates alcohol intake in both animal and human laboratory studies. We have previously demonstrated that the frequently occurring A118G single-nucleotide polymorphism (SNP) in exon 1 of the MORgene (OPRM1), which encodes an amino-acid substitution, is functional and(More)
Thus, clinical subjects were significantly more likely than controls to carry the four-repeat high transcription allele (w1⁄4 6.000, d.f.1⁄4 1, P1⁄40.014). Linkage disequilibrium tests between the VNTR and MAOA Exon 8 suggested that the two were moderately linked (D0 1⁄4 0.61; w1⁄4 1.19, d.f.1⁄41, Po0.0001). However, there were no significant differences(More)
BACKGROUND Neuropeptide Y (NPY) is a modulator of alcohol intake in animal models of alcoholism, and is potentially involved in alcohol dependence. A coding Leu7Pro polymorphism in the signal peptide of preproNPY has been described, and the Pro7 allele has been reported to correlate with increased alcohol consumption in non-dependent Finnish males.(More)